{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:57:41Z","timestamp":1772661461708,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Computed tomography (CT) of the adrenals is a common first step for investigation of primary aldosteronism (PA). However, prior studies report poor specificity, necessitating adrenal vein sampling (AVS) prior to surgical consideration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined our AVS database to determine whether CT adrenal findings could help select patients with a high likelihood of lateralization by AVS or high\u2010value blood pressure (BP) outcomes. Subjects (<jats:italic>N<\/jats:italic> = 113) with validated outcomes were divided into groups of CT \u2018positive\u2019 or CT \u2018negative\u2019 according to the presence or absence of an adrenal mass and compared for the outcomes of lateralization by AVS or proportions achieving normotension off medications following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For patients with CT adrenal masses, there was a significantly higher odds ratio (OR) for both outcomes (6.3 and 9.7, <jats:italic>p<\/jats:italic> &lt; 0.01). In subgroup analysis, age &lt;40 years carried particularly high odds for lateralization and cure when a CT mass was present (ORs 45 and 26, <jats:italic>p<\/jats:italic> &lt; 0.01). Young individuals with normal CT adrenals rarely lateralized (10 %) and, in such patients, even factors like hypokalemia, body mass index (BMI), and plasma aldosterone level did not change the result on regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010imaged adrenal masses strongly predicted lateralization by AVS and normotension with surgical treatment of lateralized PA. In PA, CT\u2010positive patients should indeed be offered AVS and\/or surgery given the high chance of good outcomes; younger CT\u2010negative patients should be advised of a low chance of finding surgical disease by AVS.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-014-2694-9","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T14:52:08Z","timestamp":1404744728000},"page":"2855-2862","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Despite Limited Specificity, Computed Tomography Predicts Lateralization and Clinical Outcome in Primary Aldosteronism"],"prefix":"10.1002","volume":"38","author":[{"given":"G. A.","family":"Kline","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Faculty of Medicine University of Calgary 1820 Richmond Rd SW T2T 5C7 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. C.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"So","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001013"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010200311000\u201000025"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067355"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900407"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010004\u20107496\u2010z"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031337"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20103046"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283559a03"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.04.004"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21132"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20102055"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010004\u20102308\u20102"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.497"},{"key":"e_1_2_8_15_2","first-page":"299","article-title":"Primary hyperaldosteronism and adrenal incidentaloma: an argument for physiologic testing before adrenalectomy","volume":"41","author":"McAlister FA","year":"1998","journal-title":"Can J Surg"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1066"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20100104"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010013\u20102871\u20103"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.07.007"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20101917"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100878"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20102245"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070123"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00050107"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-014-2694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-014-2694-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-014-2694-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:20:49Z","timestamp":1703632849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-014-2694-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,8]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1007\/s00268-014-2694-9"],"URL":"https:\/\/doi.org\/10.1007\/s00268-014-2694-9","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,8]]}}}