{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:22:08Z","timestamp":1759335728942},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) symptoms are commonly reported in primary hyperparathyroidism (pHPT). Although a calcium\u2010mediated cause\u2010and\u2010effect relationship has been suggested, it remains unknown if parathyroidectomy improves GERD symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over a 22\u2010month period, 1,175 (39 %) of 3,000 consecutive adult patients with pHPT and symptomatic GERD (on prescription reflux medications daily for \u22652 years) undergoing parathyroidectomy were entered into a prospective study. Standardized Frequency Scale for Symptoms of GERD (FSSG) questionnaire was used to assess symptoms before, 1 and 2 years after parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Daily prescription medication was used by 81 %, while 19 % used daily non\u2010prescription drugs, both for a mean of 2.9 \u00b1 0.7 years. GERD symptoms improved (26 %) or resolved completely (36 %) in 62 % of patients (<jats:italic>p<\/jats:italic> &lt; 0.0001 vs. preoperative baseline) 1 year after parathyroidectomy. Prescription medications for GERD decreased from 81 % of enrolled patients to 26 % (<jats:italic>p<\/jats:italic> &lt; 0.0001) 12\u00a0months postoperatively, with 39 % having complete symptom relief and taking no medications (<jats:italic>p<\/jats:italic> &lt; 0.0001). Daily use of prescription GERD medications decreased to occasional over\u2010the\u2010counter drug use in 35 % after parathyroidectomy (<jats:italic>p<\/jats:italic> &lt; 0.0001). Mean FSSG scores decreased significantly postoperatively (pre\u2010op: 18.0 \u00b1 8.0 vs. post\u2010op: 10.0 \u00b1 5.0; <jats:italic>p<\/jats:italic> &lt; 0.0001), with significant improvements in all 12 FSSG categories, including motility (pre\u2010op: 7.3 \u00b1 3.0 vs. post\u2010op: 4.4 \u00b1 3.0; <jats:italic>p<\/jats:italic> &lt; 0.0001) and acid reflux symptoms (pre\u2010op: 10.8 \u00b1 5.0 vs. post\u2010op: 5.9 \u00b1 4.0; <jats:italic>p<\/jats:italic> &lt; 0.0001). Symptomatic improvements were durable 2 years after parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Symptomatic GERD is common in pHPT. Parathyroidectomy provides significant, durable relief of both motility and acid reflux symptoms allowing discontinuation of prescription drug use for GERD in most (74 %) patients providing yet another indication for parathyroidectomy in pHPT.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-014-2876-5","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T15:54:41Z","timestamp":1416585281000},"page":"706-712","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical Cure of Primary Hyperparathyroidism Ameliorates Gastroesophageal Reflux Symptoms"],"prefix":"10.1002","volume":"39","author":[{"given":"James","family":"Norman","sequence":"first","affiliation":[{"name":"Norman Parathyroid Center Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Politz","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Lopez","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deva","family":"Boone","sequence":"additional","affiliation":[{"name":"Norman Parathyroid Center Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stojadinovic","sequence":"additional","affiliation":[{"name":"Bon Secours Cancer Institute Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.316"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP12207.OR"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00487.2006"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750128"},{"issue":"12","key":"e_1_2_7_6_2","first-page":"412","article-title":"Clinical manifestations of primary hyperparathyroidism before and after parathyroidectomy. 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