{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:22:28Z","timestamp":1704932548410},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although long\u2010term observation of ground glass nodules on computed tomography facilitates the ability to distinguish malignant lesions from benign lesions, the resulting treatment delay can increase the rate of cancer recurrence. We reviewed our surgical cases of pathologically undiagnosed lung nodules possessing ground glass to clarify the clinical impact of selecting surgical candidates based on serial computed tomography, not preoperative biopsy results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive series of 100 patients with clinically suspected lung cancer possessing ground glass among our prospective database of 262 surgical cases of suspected lung cancer were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgical indication was determined based on the interval change in the outer diameter or internal attenuation of the lesions in 53 patients (increasing lesions), while that was determined based on the specific marginal or internal features of the lesions in 47 patients (non\u2010increasing lesions). The length of preoperative follow\u2010up was significantly longer in the patients with increasing lesions than in the patients with non\u2010increasing lesions (27 vs. 3\u00a0months, <jats:italic>P<\/jats:italic> &lt; 0.001). The final pathological diagnoses consisted of 97 adenocarcinomas and three non\u2010malignant lesions. All increasing lesions were adenocarcinomas. Surgical biopsy contributed in avoiding futile lobectomy in patients with non\u2010malignant lesions, while that caused false\u2010negative result in one patient with an increasing lesion. Postoperative recurrence occurred in two patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a surgical series, serial computed tomography\u2010diagnosed ground glass lesions are highly suggestive of adenocarcinoma, especially increasing lesions. Despite spending a long\u2010term preoperative follow\u2010up period without a pathological diagnosis, the surgical outcome is satisfactory. Surgical biopsy for increasing lesions is generally futile.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-2979-7","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T16:12:49Z","timestamp":1423066369000},"page":"1452-1459","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgery for Undiagnosed Ground Glass Pulmonary Nodules: Decision Making Using Serial Computed Tomography"],"prefix":"10.1002","volume":"39","author":[{"given":"Kazuhiro","family":"Ueda","sequence":"first","affiliation":[{"name":"Division of Chest Surgery, Department of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine 1\u20101\u20101 Minami\u2010Kogushi 755\u20108505 Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Chest Surgery, Department of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine 1\u20101\u20101 Minami\u2010Kogushi 755\u20108505 Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Radiopathology and Science Yamaguchi University Graduate School of Medicine 1\u20101\u20101 Minami\u2010Kogushi 755\u20108505 Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Hoshii","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Yamaguchi University Graduate School of Medicine 1\u20101\u20101 Minami\u2010Kogushi 755\u20108505 Ube Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery NHO Yamaguchi\u2010Ube Medical Center 685 Higashi\u2010kiwa 755\u20100241 Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Hamano","sequence":"additional","affiliation":[{"name":"Division of Chest Surgery, Department of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine 1\u20101\u20101 Minami\u2010Kogushi 755\u20108505 Ube Yamaguchi 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