{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:26:42Z","timestamp":1768681602235,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peritoneal\u2010based malignancy (PBM), especially peritoneal carcinomatosis from gastrointestinal malignancies traditionally carries a poor prognosis. Cytoreductive surgery (CRS) and hyperthermic intra\u2010peritoneal chemotherapy (HIPEC) have been shown to attain long median survival of 34\u201392\u00a0months and 5 year survival of 29\u201359 % in patients with favorable histopathological subtypes. Recurrence after CRS and HIPEC poses a management dilemma. This paper evaluates our institution\u2019s experience with repeat CRS and HIPEC, its associated morbidity and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred and thirty underwent CRS and HIPEC for PBM from April 2001 to June 2013. 49 had peritoneal recurrences, of which 24 had peritoneal only recurrence. 7 out of the 24 underwent a second CRS and HIPEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five females and two males with median age of 51 (37\u201363), underwent a second CRS and HIPEC. The primary malignancies were: 1 peritoneal mesothelioma, 3 appendiceal, 2 ovarian, and 1 colorectal cancers. Median peritoneal cancer indices for the initial and second CRS were 19 and 12, respectively. Completeness of cytoreduction score of 0 was achieved for all patients. Median hospitalization after second CRS and HIPEC was 12\u00a0days (7\u201360). 1 out of 7 (14 %) experienced grade 3 or 4 post\u2010operative complications. There was no 30\u2010day or inpatient mortality. Median follow\u2010up was 13\u00a0months (1\u201397). Median disease\u2010free interval between the first CRS and HIPEC to peritoneal recurrence was 20\u00a0months (14\u201387). Median disease\u2010free survival of 6\u00a0months (1\u201397) was achieved after the second CRS and HIPEC. Six patients remained alive without disease and one passed away with disease. Two had recurrences at 12 and 71\u00a0months after second CRS and HIPEC, 1 died and the other, still alive, went on to have a third CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeat CRS and HIPEC can achieve prolonged survival in selected patients with peritoneal\u2010based malignancies, and can be performed with acceptable morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-2986-8","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T16:54:50Z","timestamp":1423068890000},"page":"1578-1583","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Repeat Cytoreductive Surgery and HIPEC for Peritoneal Surface Malignancy and Peritoneal Carcinomatosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Joelle F. S.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology National Cancer Centre 11 Singapore General Hospital, Outram Road 169608 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace H. C.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology National Cancer Centre 11 Singapore General Hospital, Outram Road 169608 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weining","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology National Cancer Centre 11 Singapore General Hospital, Outram Road 169608 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. C.","family":"Soo","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology National Cancer Centre 11 Singapore General Hospital, Outram Road 169608 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C. C.","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology National Cancer Centre 11 Singapore General Hospital, Outram Road 169608 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1021"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(20000115)88:2<358::AID\u2010CNCR16>3.0.CO;2\u2010O"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107819\u20107\u20105"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010006\u20109182\u2010x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048\u2010891x.2004.14008.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23553"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010007\u20109487\u20104"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.09.006"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101438.2006.00314.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9640"},{"key":"e_1_2_7_14_2","first-page":"231","article-title":"Mortality and morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and peritoneal carcinomatosis","volume":"29","author":"Saxena A","year":"2013","journal-title":"Viszeralmedizin \u2010 Gastrointest Med Surg"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199501000\u201000004"},{"key":"e_1_2_7_16_2","volume-title":"Technical handbook for the integration of cytoreductive surgery and perioperative intraperitoneal chemotherapy into the surgical management of gastrointestinal and gynecologic malignancy","author":"Sugarbaker PH","year":"2005"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)70539\u20108"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199402000\u201000002"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200308000\u201000006"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000152015.76731.1f"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.04.023"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V39N1p54"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.3747\/co.v18i2.663"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9285"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.08.024"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900560"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23356"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-015-2986-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-015-2986-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-015-2986-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:17:03Z","timestamp":1704928623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-015-2986-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,5]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1007\/s00268-015-2986-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-015-2986-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,5]]}}}