{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:15:07Z","timestamp":1776082507054,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prophylactic combined extrahepatic bile duct resection remains controversial for locally advanced gallbladder carcinoma without extrahepatic bile duct invasion. The aim of this study is to resolve this issue and establish an appropriate surgery for locally advanced gallbladder carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 52 patients underwent surgical resection combined with extrahepatic bile duct resection for locally advanced gallbladder carcinoma without extrahepatic bile duct invasion, and their medical records were retrospectively reviewed for microvessel invasion (MVI), including lymphatic, venous, and\/or perineural invasions, around the extrahepatic bile duct.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 52 patients, 8 (15 %) had MVI around the extrahepatic bile duct. All of the 8 patients had Stage IV disease. According to a survival analysis of the 50 patients who tolerated surgery, MVIs around the extrahepatic bile duct and distant metastasis were identified as independent prognostic factors. Survival for patients with MVI around the extrahepatic bile duct was dismal, with a lack of 2\u2010year survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MVI around the extrahepatic bile duct is a sign of extremely locally advanced gallbladder carcinoma; therefore, prophylactic combined bile duct resection has no survival impact for patients without extrahepatic bile duct invasion.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3011-y","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T17:10:54Z","timestamp":1423242654000},"page":"1810-1817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined Extrahepatic Bile Duct Resection for Locally Advanced Gallbladder Carcinoma: Does It Work?"],"prefix":"10.1002","volume":"39","author":[{"given":"Tsuyoshi","family":"Igami","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318216f5f3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340100021"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2002.02001.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010003\u20107080\u2010y"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(01)00814\u20106"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010006\u20109097\u20106"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010008\u20100189\u20103"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010013\u20101120\u20103"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12188"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.04.032"},{"key":"e_1_2_5_12_2","volume-title":"International Union Against Cancer (UICC). TNM classification of malignant tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010007\u20109324\u20108"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010008\u20100008\u2010z"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780629"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000094437.68038.a3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20585"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010009\u20100101\u2010y"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2002.02184.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20109950\u20104"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595\u2010009\u20103960\u20106"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ae29d6"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-015-3011-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-015-3011-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-015-3011-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:42:01Z","timestamp":1703634121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-015-3011-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1007\/s00268-015-3011-y"],"URL":"https:\/\/doi.org\/10.1007\/s00268-015-3011-y","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,7]]}}}