{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:15:23Z","timestamp":1783487723213,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Twenty\u2010two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were &lt;45 years old. We compared clinicopathologic characteristics and outcomes between patients with DSV and those with classical PTC &lt;45 years old. Univariate analysis by the Kaplan\u2013Meier method in relation to cause\u2010specific survival (CSS) and disease\u2010free survival (DFS) rates was performed with regard to the following variables: sex; anti\u2010thyroglobulin antibody (TgAb) positivity; presence of distant metastasis; pathological lymph node metastasis; extra\u2010thyroidal invasion; and pathological variant (classical vs. DSV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 20 patients with DSV &lt;45 years old comprised 18 females and 2\u00a0males. Frequencies of TgAb, pN1b, and local recurrence were higher in the DSV group than in the classical PTC group. Ten\u2010year CSS and DFS rates for PTC patients &lt;45 years old were 99.7 and 88.6 % in the classical PTC group and 100 and 60.5 % in the DSV group. CSS rate did not differ between groups, but DFS rate was significantly lower in the DSV group than in the classical PTC group (<jats:italic>p<\/jats:italic> &lt; 0.0001, log\u2010rank test). Multivariate analysis identified DSV group and pN1b as prognostic factors for recurrence in young PTC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most DSV patients were young and had a background of chronic thyroiditis. Outcomes for DSV were very good, but recurrence was more common than in classical PTC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3021-9","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T17:07:40Z","timestamp":1425575260000},"page":"1728-1735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Clinicopathologic Features and Outcomes in Patients with Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Junko","family":"Akaishi","sequence":"first","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio Hospital 35, Shinanomachi, Shinjuku\u2010ku 160\u20108582 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Matsuzu","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Uruno","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ohkuwa","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuji","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Nippon Medical School 1\u20101\u20105, Sendagi, Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"90","article-title":"Papillary carcinoma","volume":"2","author":"Vickery AL","year":"1985","journal-title":"Sem Diagn Pathol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19890301)63:5<908::AID\u2010CNCR2820630520>3.0.CO;2\u2010I"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010198912000\u201000006"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344\u20100338(89)80252\u20103"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.1989.tb01277.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19901201)66:11<2306::AID\u2010CNCR2820661109>3.0.CO;2\u2010P"},{"key":"e_1_2_7_8_2","first-page":"193","article-title":"Diffuse sclerosing variant of papillary carcinoma of the thyroid. 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