{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:44:48Z","timestamp":1787701488084,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to analyze the clinical features and clinical outcomes of papillary thyroid carcinoma (PTC) in the pediatric and adolescent population treated in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were 227\u00a0PTC patients 20 years of age or under treated initially between 1979 and 2012. Their mean age at diagnosis was 18\u2010year old (range 7\u201320 years). Patient characteristics and outcomes in the period before 1999 and the period after 2000 were compared. Cause\u2010specific survival (CSS) rates and disease\u2010free survival (DFS) rates were calculated by the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients died of their disease and 45 patients had recurrent disease (36\u00a0in lymph node, seven in a remnant thyroid, and 11\u00a0in the form of distant metastasis). The 10\u2010, 20\u2010, and 30\u2010CSS rates were 99.3, 99.3, and 96.5 %, respectively, and the 10\u2010, 20\u2010, and 30\u2010DFS were 83.6, 70.7, and 64.0 %, respectively. Gender and preoperative lymph node metastasis were identified as significant factors related to DFS in the multivariate analysis. After the year 2000, there were significantly more patients with a small primary tumor size, significantly more patients without distant metastasis at presentation and significantly more patients without extrathyroidal invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of patients with advanced cancer has been declining in recent years. Lobectomy with prophylactic unilateral central neck dissection is considered acceptable for patients without the risk factors for recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3042-4","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T16:21:38Z","timestamp":1427127698000},"page":"2259-2265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Papillary Thyroid Carcinoma in Children and Adolescents: Long\u2010Term Follow\u2010Up and Clinical Characteristics"],"prefix":"10.1002","volume":"39","author":[{"given":"Kiminori","family":"Sugino","sequence":"first","affiliation":[{"name":"Department of Surgery Ito Hospital Tokyo 4\u20103\u20106 Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuji","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito 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