{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:55:56Z","timestamp":1768096556916,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Switzerland is a region in which alveolar echinococcosis (AE) is endemic. Studies evaluating outcomes after liver resection (LR) for AE are scarce. The aim of this study was to assess the short\u2010 and long\u2010term outcomes of AE patients after LR in a single tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data pertaining to all patients with liver AE who were treated with LR at our institution between January 1992 and December 2013. Patient demographics, intraoperative data, extent of LR procedures (major vs. minor LR), postoperative outcomes, and negative histological margin (R0) resection rate were recorded in a database. Recurrence rates after LR were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LR was performed in 59 patients diagnosed with hepatic AE (56 complete surgeries, 3 reduction surgeries). Postoperative morbidity and mortality were observed in 34 % (25 % grade I\u2013II, 9 % grade III\u2013IV) and 2 % of the patients, respectively. R0 (complete) resection rate was 71 % (<jats:italic>n<\/jats:italic>= 42), and R1\/R2 resection rate was 29 % (<jats:italic>n<\/jats:italic>= 17). Extra\u2010hepatic recurrence occurred in 1 case (lung) after R0 resection. In cases of R1\/R2 resection, 7\u00a0intra\u2010hepatic disease progressions occurred with a median time of 10\u00a0months (IQR 6\u201311\u00a0months). Long\u2010term (more than 1 year) benzimidazole treatment stabilized the disease in 64 % (9\/14) of patients with R1 status. The overall survival rate was 97 %.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver AE can be safely and definitively treated with LR, provided that R0 resection is achieved. In cases of R1 resection, benzimidazole therapy seems to be effective in stabilizing the intra\u2010hepatic disease and preventing extra\u2010hepatic recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3109-2","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T17:53:27Z","timestamp":1434045207000},"page":"2529-2534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Outcomes After Liver Resection for Hepatic Alveolar Echinococcosis: A Single\u2010Center Cohort Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Ga\u00ebtan\u2010Romain","family":"Joliat","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery University Hospital CHUV Rue du Bugnon 46 1011 Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Melloul","sequence":"additional","affiliation":[{"name":"Department of Visceral 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Bugnon 46 1011 Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermin","family":"Halkic","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery University Hospital CHUV Rue du Bugnon 46 1011 Lausanne 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