{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:56:18Z","timestamp":1761663378048},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of hepatocellular carcinoma (HCC) in patients with concomitant esophageal varices (EV) remains controversial. We assessed the surgical outcome of hepatectomy and aimed to clarify the indications and management of HCC in patients with concomitant EV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 502 patients with HCC (100 with and 402 without EV), who underwent curative hepatectomy. We analyzed the prognostic outcomes and risk factors for EV bleeding after hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival (OS) was significantly lower in HCC patients with EV than in those without EV (<jats:italic>p<\/jats:italic> = 0.003), although recurrence\u2010free survival was similar in both groups. Multivariate analysis showed that indocyanine green retention test at 15\u00a0min (ICGR<jats:sub>15<\/jats:sub>) &gt;17 % (<jats:italic>p<\/jats:italic> = 0.007) and \u03b1\u2010fetoprotein &gt;12.5\u00a0ng\/ml (<jats:italic>p<\/jats:italic> = 0.003) was independent predictors of poorer OS. Among patients with EV who underwent hepatectomy, multivariate analysis identified ICGR<jats:sub>15<\/jats:sub> &gt;17 % (<jats:italic>p<\/jats:italic> = 0.03) as the only independent predictor of poorer OS. There was no significant difference in OS between HCC patients with EV and ICGR<jats:sub>15<\/jats:sub> \u226417.0 % and HCC patients without EV. Ten patients experienced EV bleeding after hepatectomy. Multivariate analysis showed that preoperative endoscopic findings of blue color EV (<jats:italic>p<\/jats:italic> = 0.008) and red color sign (<jats:italic>p<\/jats:italic> = 0.0005) were independent predictors of EV bleeding in patients with HCC after hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that HCC patients with EV and ICGR<jats:sub>15<\/jats:sub> \u226417 % may be suitable for surgery, but patients with preoperative endoscopic blue color EV and red color sign need to be managed appropriately.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3110-9","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T05:24:31Z","timestamp":1434000271000},"page":"2510-2518","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Surgical Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices"],"prefix":"10.1002","volume":"39","author":[{"given":"Noboru","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital 730\u20108619 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medical Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital 730\u20108619 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Kayashima","sequence":"additional","affiliation":[{"name":"Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital 730\u20108619 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyoshi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Surgery Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital 730\u20108619 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medical Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100524\u20109"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010190810000\u201000005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101247133"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(96)70070\u20107"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.091"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b977a5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300629"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8753"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.027"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7672"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010011\u20101017\u20107"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.07.028"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443\u20101661.2009.00929.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2331"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010014\u20102915\u20102"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010011\u20101013\u2010y"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.045"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105107(97)70180\u20109"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.12119"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250608"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220145"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106203242505"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140612"}],"container-title":["World 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