{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:59:33Z","timestamp":1784818773139,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This paper aims to demonstrate if <jats:italic>Escherichia coli<\/jats:italic> pyogenic liver abscess (ECPLA) results in adverse outcomes compared to <jats:italic>Klebsiella pneumoniae<\/jats:italic> PLA (KPPLA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all patients admitted at a tertiary hospital in Singapore from 2003 to 2011 was performed. Patients with age &lt;18 years, amoebic liver abscess, infected liver cyst, culture negative abscess or ruptured liver abscess requiring urgent surgical intervention were excluded. Only patients with blood or pus culture confirmation of ECPLA (<jats:italic>n<\/jats:italic> = 24) or KPPLA (<jats:italic>n<\/jats:italic> = 264) were included. Median length of hospital stay, failure of non\u2010operative therapy and 30\u2010day mortality are the reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ECPLA affects older patients (68 vs. 62 years, <jats:italic>p<\/jats:italic> = 0.049). Ischemic heart disease was more common in ECPLA (29 vs. 14 %, <jats:italic>p<\/jats:italic> = 0.048) and there was no difference in diabetic state (42 vs. 38 %, <jats:italic>p<\/jats:italic> = 0.743). ECPLA is more commonly associated with hyperbilirubinemia (60 vs. 34 \u00b5mol\/L, <jats:italic>p<\/jats:italic> = 0.003), increased gamma\u2010glutamyl transpeptidase (236 vs. 16 IU\/L, <jats:italic>p<\/jats:italic> = 0.038) and gallstones (58 vs. 30 %, <jats:italic>p<\/jats:italic> = 0.004). KPPLA are larger in size (6 vs. 4\u00a0cm, <jats:italic>p<\/jats:italic> = 0.006) and had percutaneous drainage (PD) more frequently (64 vs. 42 %, <jats:italic>p<\/jats:italic> = 0.034). There was no difference in median hospital stay (14 vs. 14\u00a0days, <jats:italic>p<\/jats:italic> = 0.110) or 30\u2010day mortality (17 vs. 10 %, <jats:italic>p<\/jats:italic> = 0.307) between ECPLA and KPPLA. Among patients with ECPLA, antibiotic treatment with PD appeared to have higher mortality compared to antibiotic treatment alone (30 vs. 7 %) but this was not significant (<jats:italic>p<\/jats:italic> = 0.272).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the setting of multimodal care, outcomes of ECPLA are comparable to KPPLA.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3126-1","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T13:15:06Z","timestamp":1435756506000},"page":"2535-2542","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Pyogenic Liver Abscess: Does <i>Escherichia Coli<\/i> Cause more Adverse Outcomes than <i>Klebsiella Pneumoniae<\/i>?"],"prefix":"10.1002","volume":"39","author":[{"given":"Vishal G.","family":"Shelat","sequence":"first","affiliation":[{"name":"Department of General Surgery Tan Tock Seng Hospital 308433 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement L. 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