{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:45:33Z","timestamp":1762145133561},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A consensus has almost been reached in favor of hepatic resection for colorectal cancer metastases. It remains unclear whether resection of gastric cancer metastases in the liver is justified. The purpose of this study was to assess the survival benefit of surgical resection for gastric cancer metastases confined to the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the clinicopathological features and outcome of 107 patients with liver metastases without other non\u2010curative factors from the case records of 5437 gastric cancer patients. These subjects included 34 synchronous cases with tumors present at the time of gastrectomy and 73\u00a0metachronous cases with new lesions that appeared after radical gastrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepatectomies were performed in nine synchronous and four metachronous cases that had \u22643 tumors with diameters &lt;3\u00a0cm. The overall survival rates after hepatectomy were significantly higher than those in eligible candidates who did not receive hepatectomy despite having comparable metastatic status (synchronous, <jats:italic>n<\/jats:italic> = 8, <jats:italic>p<\/jats:italic> = 0.009; metachronous, <jats:italic>n<\/jats:italic> = 24, <jats:italic>p<\/jats:italic> = 0.016). The survival rate of patients who underwent hepatectomy for synchronous metastases was not inferior to that of patients who underwent hepatectomy for metachronous metastases. The median disease\u2010free interval in metachronous cases was significantly shorter in patients who did not undergo resection than those who underwent resection. However, multivariate analyses revealed that hepatectomy was the only significant (<jats:italic>p<\/jats:italic> = 0.001) prognostic factor whereas DFI was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatectomy for \u22643\u00a0metastatic tumors with diameters &lt;3\u00a0cm offered superior survival compared with non\u2010surgical treatment even for metastases detected synchronously or within a short period after radical gastrectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3151-0","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T19:34:48Z","timestamp":1436211288000},"page":"2757-2763","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatectomy Offers Superior Survival Compared with Non\u2010surgical Treatment for \u22643\u00a0Metastatic Tumors with Diameters &lt;3\u00a0cm from Gastric Cancer: A Retrospective Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Yu","family":"Ohkura","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Toranomon Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Toranomon Hospital Tokyo Japan"},{"name":"Department of Surgery Kyoto University Graduate School of Medicine 54 Kawara\u2010cho, Shogoin, Sakyo\u2010ku 606\u20108507 Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Haruta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Toranomon Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Toranomon Hospital Tokyo 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