{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:07:24Z","timestamp":1762542444824},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Appendiceal neuroendocrine tumors (aNET) are a common entity in routine medical care, with a rate per appendectomy as high as 0.3\u20130.9 %. Considering the relatively young age at diagnosis for these patients, exact information about the long\u2010term prognosis of aNET is required. Survival rates vary substantially between 71 and 100 % and are mostly limited to 5 years. This investigation assessed the long\u2010term mortality rates of patients who underwent aNET resections at fifteen hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1990 and 2003, the 10\u2010year survival rates of 79 patients were analyzed using risk\u2010adjusted Cox proportional hazard regression models adjusted for population\u2010based baseline mortality. Additionally, prognostic factors for the oncologic outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up of all patients was 12.1 and 13.7 years for those alive. All patients underwent curative R0 resections. No distant metastases were diagnosed. A total of 31 (39.2 %), 29 (36.7 %), 18 (22.8 %), and 1 (1.3 %) patients had stage I, IIA, IIB, and IIIB aNET, respectively, according to the latest classification by the European Neuroendocrine Tumor Society. The 10\u2010year overall and relative survival rates were 83.6 % (95 % CI 75.5\u201392.6 %) and 96.7 % (95 % CI 87.5\u2013107 %), respectively. The 10\u2010year relative survival rate after resection of aNET did not differ from the survival of the average national population with the same age and gender (<jats:italic>p<\/jats:italic> = 0.947). Second primary malignancies (hazard ratio of death 7.0, 95 % CI 1.6\u201330.6) were identified as a significant prognosticator for long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term survival is not significantly depreciated after the curative resection of aNET.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3164-8","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T14:15:02Z","timestamp":1438179302000},"page":"2670-2676","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010Term Survival is not Impaired After the Complete Resection of Neuroendocrine Tumors of the Appendix"],"prefix":"10.1002","volume":"39","author":[{"given":"Thomas","family":"Steffen","sequence":"first","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina M.","family":"Ebinger","sequence":"additional","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Warschkow","sequence":"additional","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"},{"name":"Institute of Medical Biometry and Informatics University of Heidelberg 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"L\u00fcthi","sequence":"additional","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno M.","family":"Schmied","sequence":"additional","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Clerici","sequence":"additional","affiliation":[{"name":"Department of Surgery Cantonal Hospital of St. Gallen 9007 St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23883"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000129342.67174.67"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11105"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115734"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101749\u2010z"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.04.016"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010008\u20100545\u20104"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20179"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.01.007"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335629"},{"key":"e_1_2_6_12_2","unstructured":"Bev\u00f6lkerungsbewegung\u2010Analysen\u2010J\u00e4hrliche Sterbetafeln Bundesamt f\u00fcr Statistik (2013) .http:\/\/www.bfs.admin.ch\/bfs\/portal\/de\/index\/themen\/01\/06\/blank\/dos\/la_mortalite_en_suisse\/tabl02.html. 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