{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:26:40Z","timestamp":1779229600447,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To reduce intraoperative and postoperative complications, using Lugol solution to preoperatively prepare patients with Graves\u2019 disease has (1) rapidly reduced the severity of thyrotoxicosis and (2) reduced the vascularity of the thyroid gland. The vascularity reduction normally accompanies reducing the severity of thyrotoxicosis. However, the effects and mechanism of Lugol solution for reducing blood flow have not been well investigated in the patients with euthyroid (normally functioning thyroid) Graves\u2019 disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with euthyroid Graves\u2019 disease being preoperatively treated with Lugol solution for 10\u00a0days were measured, at baseline and on the operative day, for (1) superior thyroid artery blood flow; (2) systemic angiogenic factor (VEGF); and (3) systemic inflammatory factor [interleukin (IL)\u201016].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three parameters were significantly (<jats:italic>p<\/jats:italic> &lt; 0.0001) lower after 10\u00a0days of Lugol solution treatment. The average reductions were blood flow: 60 % (0.294 vs. 0.117\u00a0L\/min), serum VEGF: 55 % (169.8 vs. 76.7 pg\/mL), and serum IL\u201016: 50 % (427.2 vs. 214.2; pg\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lugol solution significantly reduced thyroid arterial blood flow, VEGF, and IL\u201016, even in patients with euthyroid Graves\u2019 disease. We recommend routine preoperative Lugol solution treatment for all patients with Graves\u2019 disease.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3298-8","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T19:09:07Z","timestamp":1446836947000},"page":"505-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves\u2019 Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Shih\u2010Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine and Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ting","family":"Liao","sequence":"additional","affiliation":[{"name":"Clinical Research Center, College of Medicine and Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiou\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Research Center, College of Medicine and Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Sunny","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Research Center, College of Medicine and Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan\u2010Haw","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Hospital National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.2.146"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20100229"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(00)00755\u20109"},{"key":"e_1_2_5_5_2","first-page":"1955","article-title":"Results of administering iodine to patients having exophthalmic goiter","volume":"80","author":"Plummer HS","year":"1923","journal-title":"JAMA"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1660475"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.11.3908"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.02.002"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.21139"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.123"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0405"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2006.02447.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.2002.01778.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005\u20101375"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.01.017"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.942"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6348"},{"key":"e_1_2_5_18_2","first-page":"92","article-title":"Serum interleukin\u201016 and RANTES during treatment of Graves\u2019 orbitopathy with corticosteroids and teleradiotherapy","volume":"63","author":"Mysliwiec J","year":"2012","journal-title":"Endokrynol Pol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03340370075036"},{"key":"e_1_2_5_20_2","first-page":"1055","article-title":"The effect of preoperative Lugol\u2019s iodine on thyroid blood flow in patients with Graves\u2019 hyperthyroidism","volume":"102","author":"Chang DC","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3564"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3281"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.4618"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-015-3298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-015-3298-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-015-3298-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:24:48Z","timestamp":1703633088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-015-3298-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1007\/s00268-015-3298-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-015-3298-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]}}}