{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:52:12Z","timestamp":1778032332049,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study attempts to quantify the burden of disease averted through the global surgical work of a large cleft charity, and estimate the economic impact of this effort over a 10\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anonymized data of all primary cleft lip and cleft palate procedures in the Smile Train database were analyzed and disability\u2010adjusted life years (DALYs) calculated using country\u2010specific life expectancy tables, established disability weights, and estimated success of surgery and residual disability probabilities; multiple age weighting and discounting permutations were included. Averted DALYs were calculated and gross national income (GNI) per capita was then multiplied by averted DALYs to estimate economic gains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>548,147 primary cleft procedures were performed in 83 countries between 2001 and 2011. 547,769 records contained complete data available for the study; 58 % were cleft lip and 42 % cleft palate. Averted DALYs ranged between 1.46 and 4.95\u00a0M. The mean economic impact ranged between USD 5510 and 50,634 per person. This corresponded to a global economic impact of between USD 3.0B and 27.7B USD, depending on the DALY and GNI values used. The estimated cost of providing these procedures based on an average reimbursement rate was USD 197M (0.7\u20136.6 % of the estimated impact).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The immense economic gain realized through procedures focused on a small proportion of the surgical burden of disease highlights the importance and cost\u2010effectiveness of surgical treatment globally. This methodology can be applied to evaluate interventions for other conditions, and for evidence\u2010based health care resource allocation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3367-z","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T18:29:44Z","timestamp":1450204184000},"page":"1053-1059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Economic Valuation of the Global Burden of Cleft Disease Averted by a Large Cleft Charity"],"prefix":"10.1002","volume":"40","author":[{"given":"Dan","family":"Poenaru","sequence":"first","affiliation":[{"name":"MyungSung Christian Medical Center, Addis Ababa Ethiopia and Montreal Children\u2019s Hospital Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Corlew","sequence":"additional","affiliation":[{"name":"2111 Riverview Drive 37129 Murfreesboro TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1596\/978-0-8213-6262-4"},{"issue":"8","key":"e_1_2_7_3_2","first-page":"981","article-title":"A critical examination of summary measures of population health","volume":"78","author":"Murray CJL","year":"2000","journal-title":"Bull WHO"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.23.100901.140513"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20100198\u20109"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101796\u20105"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.8.PEDS11163"},{"key":"e_1_2_7_8_2","unstructured":"Tan\u2010Torres EdejerT BaltussenR AdamT HutubessyR AcharyaA EvansDB MurrayCJL eds (2003).WHO Guide to cost\u2014effectiveness analysis. Geneva pp1\u2013239"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010011\u20101055\u20101"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034595"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101876\u20106"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020\u20107292(03)00072\u20109"},{"key":"e_1_2_7_13_2","unstructured":"Smile Train: leading children\u2019s charity.www.smiletrain.org. Accessed March 31 2014"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010014\u20102516\u20100"},{"key":"e_1_2_7_15_2","first-page":"1","volume-title":"The global burden of disease","author":"Murray CJL","year":"1996"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20100261\u20106"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1596\/978-0-8213-6262-4"},{"key":"e_1_2_7_18_2","unstructured":"World Health Organization(2015)Standard Life Tables. Who.int\/healthinfo\/bodreferencesstandardlifetable.xls. Accessed Jan 21"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.208"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20100230\u20100"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100609\u20105"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101899\u2010z"},{"issue":"3","key":"e_1_2_7_23_2","first-page":"495","article-title":"The global burden of disease in 1990: summary results, sensitivity analysis and future direction","volume":"72","author":"Murray CJL","year":"1994","journal-title":"Bull WHO"},{"key":"e_1_2_7_24_2","unstructured":"World Bankwebsite:http:\/\/databank.worldbank.org\/data\/views\/reports\/tableview.aspx. Accessed Jan 21 2015"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","unstructured":"HughesCDet al. The Clinical and economic impact of a sustained program in global plastic surgery: valuing cleft care in resource\u2010poor settings.PRS(2012)","DOI":"10.1097\/PRS.0b013e318254b2a2"},{"issue":"3","key":"e_1_2_7_26_2","first-page":"1","article-title":"Cleft lip and palate surgery carried out by one team in Uganda: where have all the palates gone?","volume":"49","author":"Wilson J","year":"2011","journal-title":"Cleft Palate Craniofac J"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050121"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101808\u20105"},{"key":"e_1_2_7_29_2","doi-asserted-by":"crossref","unstructured":"AlkireB VincentJ MearaJ(2014)Benefit\u2010cost analysis of a cleft lip and palate surgical subspecialty hospital in India. In DCP3 draft pp1\u201317","DOI":"10.4103\/2348-2125.126544"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101761\u20103"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010013\u20102182\u20107"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102014\u2010306175"},{"key":"e_1_2_7_33_2","unstructured":"BloomDEandCanningD(2008) Population health and economic growth Working paper 24 Commission on Growth and Development The World Bank"},{"key":"e_1_2_7_34_2","unstructured":"BanerjeeAV DufloE(2012)Poor economics: a radical rethinking of the way to fight global poverty Public Affairs"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-015-3367-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-015-3367-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-015-3367-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:23:34Z","timestamp":1703633014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-015-3367-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1007\/s00268-015-3367-z"],"URL":"https:\/\/doi.org\/10.1007\/s00268-015-3367-z","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}