{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:57:37Z","timestamp":1769155057858,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to assess the prognostic impact of preoperative transcatheter arterial chemoembolization (TACE) on long\u2010term survival outcomes in patients undergoing resection of small solitary hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Enrolled patients had undergone macroscopic curative resection of solitary 2\u20135\u00a0cm HCC with (<jats:italic>n<\/jats:italic> = 105) or without (<jats:italic>n<\/jats:italic> = 830; control group) preoperative TACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TACE group was divided into subgroups A (<jats:italic>n<\/jats:italic> = 68, 1\u20132 TACEs within 12\u00a0months), B (<jats:italic>n<\/jats:italic> = 23, \u22653 TACEs within 12\u00a0months), and C (<jats:italic>n<\/jats:italic> = 14, TACE prior to 12\u00a0months). The number of TACE sessions was 1.8 \u00b1 1.6. In TACE A\u2010C subgroups, pathological response of tumor necrosis &gt;50 % at median post\u2010TACE period after final TACE was observed in 41 (60.3 %) at 1.9\u00a0months, 10 (43.5 %) at 2.1\u00a0months, and 2 (14.3 %) at 18.9\u00a0months, respectively. The 5\u2010year tumor recurrence and patient survival rates were 62.8 and 70.4 % in TACE group and 51.4 and 83.4 % in control group, respectively (<jats:italic>p<\/jats:italic> \u2264 0.003). Median periods of postoperative tumor recurrence in TACE A\u2010C subgroups and control group were 35, 13, 14, and 55\u00a0months, respectively (<jats:italic>p<\/jats:italic> &lt; 0.001); and postoperative survival periods at 75 % survival rate were 51, 38, 51, and 98\u00a0months, respectively (<jats:italic>p<\/jats:italic> = 0.003). TACE\u2010induced extensive tumor necrosis did not improve postoperative prognosis in TACE A subgroup (<jats:italic>p<\/jats:italic> \u2265 0.053). Postoperative prognosis after preoperative sequential TACE and portal vein embolization was comparable to that of the control group (<jats:italic>p<\/jats:italic> \u2265 0.052).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative TACE for small solitary HCCs may adversely affect post\u2010resection prognosis, irrespective of pathological responses. Preoperative TACE should be avoided for patients with resectable small HCCs.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3373-1","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T19:29:57Z","timestamp":1450121397000},"page":"1200-1210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Absence of Benefit of Transcatheter Arterial Chemoembolization (TACE) in Patients with Resectable Solitary Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Tae\u2010Yong","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine 88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine 88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine 88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine 88 Olympic\u2010ro 43\u2010gil, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi\u2010Young","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Asan Medical Center University of Ulsan College of Medicine Seoul 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