{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:29:45Z","timestamp":1774625385961,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholecystectomy might contribute to the development of hepatic steatosis through metabolic changes. The biologic alteration of the enterohepatic circulation of bile acids and the alteration of the metabolic activity of bile acid that follows cholecystectomy may contribute to hepatic steatosis. This prospective study was conducted to clarify the possibility of steatosis development after cholecystectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2013 to July 2014, 82 consecutive patients with a presumptive diagnosis of gallbladder disease were cholecystectomized. Liver parenchymal steatosis was measured using ultrasound and the hepatic steatosis index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all 82 patients, the hepatic steatosis index was found to be significantly correlated with the US fatty liver grade (Spearman\u2019s correlation <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.331, <jats:italic>P<\/jats:italic> &lt; 0.001). A total of 62 patients were followed up for 3\u00a0months. Comparison with the initial grade showed that 12 (18.5 %) patients had worsened from normal to mild (<jats:italic>n<\/jats:italic> = 10), from mild to moderate (<jats:italic>n<\/jats:italic> = 1), and from mild to severe (<jats:italic>n<\/jats:italic> = 1). The other patients stayed at their initial grade except one patient who improved (from moderated to mild). Analysis of laboratory findings showed that white blood cell count, aspartate transaminase, alanine transaminase level, and total bilirubin level were decreased. However, serum albumin and high\u2010density lipoprotein cholesterol levels significantly increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatic steatosis significantly developed 3\u00a0months after cholecystectomy. Therefore, cholecystectomy might be considered a risk factor for hepatic steatosis, but the relationship should be confirmed with long\u2010term follow\u2010up from a large group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-015-3396-7","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T17:03:47Z","timestamp":1453395827000},"page":"1412-1421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cholecystectomy Causes Ultrasound Evidence of Increased Hepatic Steatosis"],"prefix":"10.1002","volume":"40","author":[{"given":"Sangchul","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Surgery Soonchunhyang University Seoul Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Kyeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiology Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Sam","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Pathology Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i31.4215"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157339910793360879"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2005.03924.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010008\u20100704\u20107"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.643481"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.01.026"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010132\u20102\u2010200001180\u201000004"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.70"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.737"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210109"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24702"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2010.02361.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.001"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12\u2010s064"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.002"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6891"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.09.006"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21874"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22363"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22941"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22286"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197312062892302"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108705"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.7.640"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.03.019"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014412"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1083503"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700330\u2010JLR200"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.5.8850"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056843"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i12.3614"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2007.01526.x"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-015-3396-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-015-3396-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-015-3396-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T16:45:01Z","timestamp":1703609101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-015-3396-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1007\/s00268-015-3396-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-015-3396-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]}}}