{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:33:50Z","timestamp":1764905630683},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\nNeuroendocrine Neoplasms of the small intestine have been noticed more frequently over the past 35 years. They constitute about 25 % of all NENs and 29 % of all tumors of the small intestine. Due to the predominantly indolent nature and overall good prognosis, the benefit of surgical treatment is still debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study, data of 83 surgically treated patients with neuroendocrine neoplasms of the small intestine, 48\u00a0males and 35 females with a median age of 62 years (range 25\u201386 years) were analyzed. Patient data were documented in the MaDoc database for neuroendocrine tumors of the University Medical Center of Mainz. IBM SPSS Statistics 20 was used for statistical analysis. Kaplan\u2013Meier survival curves and Log\u2010Rank tests, censoring patients at the time of last follow\u2010up, were used to compare the overall survival depending on potential prognostic factors (stage, grade, surgical treatment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the time of diagnoses, the most common clinical symptoms were abdominal pain (<jats:italic>n<\/jats:italic> = 31, 37.3 %), bowel obstruction (<jats:italic>n<\/jats:italic> = 11, 13.3 %), bowel perforation and peritonitis (<jats:italic>n<\/jats:italic> = 3, 3.6 %), gastrointestinal bleeding (<jats:italic>n<\/jats:italic> = 9, 10.8 %), weight loss (<jats:italic>n<\/jats:italic> = 11, 13.3 %), and carcinoid syndrome (<jats:italic>n<\/jats:italic> = 27, 32.5 %). 65 patients (78.3 %) had lymph node metastasis and in 58 patients (69.9 %) distant metastasis were present. Segmental bowel resection (44) was the most common surgical procedure, followed by right hemi\u2010colectomy (32) and explorative laparotomy (7). In most patients (78.9 %), lymphadenectomy (systematic\/selective) was performed. The 5\u2010year survival of patients who underwent a systematic or a selective lymphadenectomy differed significantly (82.2 vs. 40.0 %). The overall 3\u2010, 5\u2010, and 10\u2010year survival rates were 88.2, 80.3, and 71.0 %, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mesenteric lymph node metastases are almost invariably present and have significant impact on patients\u2019 prognosis. Systematic lymphadenectomy prevents complications and improves the survival. Early surgical treatment should be the goal in order to prevent complications.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3432-2","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T17:23:08Z","timestamp":1454001788000},"page":"749-758","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Surgical Treatment of NEN of Small Bowel: A Retrospective Analysis"],"prefix":"10.1002","volume":"40","author":[{"given":"F. M.","family":"Watzka","sequence":"first","affiliation":[{"name":"Clinic of General, Visceral\u2010 and Transplantation Surgery University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fottner","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolic Diseases University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miederer","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolic Diseases University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schad","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lang","sequence":"additional","affiliation":[{"name":"Clinic of General, Visceral\u2010 and Transplantation Surgery University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Musholt","sequence":"additional","affiliation":[{"name":"Clinic of General, Visceral\u2010 and Transplantation Surgery University Medicine Mainz Langenbeckstr. 1 55131 Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818e4641"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.12.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010007\u20100452\u20101"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23549"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25855"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010011\u20101296\u2010z"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(05)80529\u2010X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200707"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000161981.58631.ab"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/0\u2010387\u201029512\u20107_7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC\u201009\u20100042"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20188"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.07.042"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00104\u2010011\u20102070\u20103"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v2.i10.325"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010232"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010013\u20101918\u20108"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3432-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-016-3432-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-016-3432-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:24:01Z","timestamp":1703633041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-016-3432-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1007\/s00268-016-3432-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-016-3432-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}