{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:37Z","timestamp":1791393457225,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\nPostoperative liver failure (PHLF) is one of the most common complications following major hepatectomy. The preoperative assessment of future liver remnant (FLR) function is critical to predict the incidence of PHLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy of the plasma clearance rate of indocyanine green clearance of FLR (ICGK\u2010F) in predicting PHLF in cases of highly invasive hepatectomy with extrahepatic bile duct resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five hundred and eighty\u2010five patients who underwent major hepatectomy with extrahepatic bile duct resection, from 2002 to 2014\u00a0in a single institution, were evaluated. Among them, 192 patients (33 %) had PHLF. The predictive value of ICGK\u2010F for PHLF was determined and compared with other risk factors for PHLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of PHLF was inversely proportional to the level of ICGK\u2010F. With multivariate logistic regression analysis, ICGK\u2010F, combined pancreatoduodenectomy, the operation time, and blood loss were identified as independent risk factors of PHLF. The risk of PHLF increased according to the decrement of ICGK\u2010F (the odds ratio of ICGK\u2010F for each decrement of 0.01 was 1.22; 95 % confidence interval 1.12\u20131.33; <jats:italic>P<\/jats:italic> &lt; 0.001). Low ICGK\u2010F was also identified as an independent risk factor predicting the postoperative mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ICGK\u2010F is useful in predicting the PHLF and mortality in patients undergoing major hepatectomy with extrahepatic bile duct resection. This criterion may be useful for highly invasive hepatectomy, such as that with extrahepatic bile duct resection.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3441-1","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T16:08:42Z","timestamp":1456157322000},"page":"1440-1447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The Predictive Value of Indocyanine Green Clearance in Future Liver Remnant for Posthepatectomy Liver Failure Following Hepatectomy with Extrahepatic Bile Duct Resection"],"prefix":"10.1002","volume":"40","author":[{"given":"Yukihiro","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya 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