{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:11:24Z","timestamp":1789708284868,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["Grand-in-Aid for Scientific Research (26462067)"],"award-info":[{"award-number":["Grand-in-Aid for Scientific Research (26462067)"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["26462067"],"award-info":[{"award-number":["26462067"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying novel predictors of hematogenous metastasis is essential to select optimal therapeutic strategies for pancreatic cancer. The goal of this study was to clarify the clinical implications of p53 and platelet\u2010derived growth factor receptor\u2010\u03b2 (PDGFR\u2010\u03b2) in pancreatic cancer using immunohistochemistry (IHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Specimens obtained by surgical resection and endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EUS\u2013FNA) of the primary tumor were used for IHC. EUS\u2013FNA was performed before any treatment. We analyzed the clinical implications of p53 and PDGFR\u2010\u03b2 IHC. We also performed a comparative analysis of the IHC findings between surgical and EUS\u2013FNA specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study involved 149 patients (120 who did not receive and 29 who received preoperative therapy). EUS\u2013FNA specimens were obtained from 20 patients without preoperative therapy and 20 patients with preoperative therapy. Abnormal p53 and high PDGFR\u2010\u03b2 expression was significantly correlated with a high incidence of hematogenous metastasis (<jats:italic>p<\/jats:italic> &lt; 0.001) and poor postoperative survival (<jats:italic>p<\/jats:italic> = 0.006). In patients without preoperative therapy, the results for p53 and PDGFR\u2010\u03b2 staining were concordant between surgical and EUS\u2013FNA specimens in 95 % of the cases. In patients with preoperative therapy, 80 and 70 % of the patients showed consistent p53 and PDGFR\u2010\u03b2 expression between surgical and EUS\u2013FNA specimens, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pancreatic cancer patients with simultaneous abnormal p53 and high PDGFR\u2010\u03b2 expression have a significantly higher risk of hematogenous metastasis and a poor prognosis after surgery. IHC evaluation using EUS\u2013FNA specimens may be able to identify patients with highly metastatic pancreatic cancer who may benefit from aggressive therapeutic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3477-2","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T17:25:11Z","timestamp":1457025911000},"page":"1977-1984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impact of p53 and PDGFR\u2010\u03b2 Expression on Metastasis and Prognosis of Patients with Pancreatic Cancer"],"prefix":"10.1002","volume":"40","author":[{"given":"Hiroshi","family":"Kurahara","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences Kagoshima University 8\u201035\u20101, Sakuragaoka 890\u20108520 Kagoshima 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