{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:11:02Z","timestamp":1782515462351,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\nPrior studies have examined the use of liver function tests (LFT) for predicting the presence of common bile duct (CBD) stones in chronic cholecystitis (CC) patients. It is currently unclear whether LFT are also useful for predicting CBD stones in patients with acute cholecystitis (AC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\nOf 1059 patients who visited an emergency room with gallbladder\u2010related symptoms between March 2004 and December 2009, 854 patients were analyzed, and were divided into three groups (556 AC patients without CBD stones (AC \u2013 CBD), 98 AC patients with CBD stones (AC + CBD), and 200 CC patients without CBD stones). We compared the LFT values at admission and the changes in LFT values over time following admission among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\nThe LFT values were significantly greater in the AC + CBD group than in the AC \u2212 CBD groups. Of all the LFT variables analyzed, <jats:italic>\u03b3<\/jats:italic>\u2010glutamyl transpeptidase was the most reliable variable for predicting the presence of CBD stones, with a sensitivity of 80.6 % and a specificity of 75.3 % at the cut\u2010off level of 224 IU\/L. The elevated LFT values decreased significantly from the start of the follow\u2010up assessment to before cholecystectomy in the AC \u2212 CBD group, but were unchanged before stone removal in the AC + CBD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\nThe LFT values on initial admission and the changes in LFT values over time are reliable predictors of CBD stones in patients with AC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3517-y","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T18:43:35Z","timestamp":1461091415000},"page":"1925-1931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Use of Liver Function Tests as First\u2010line Diagnostic Tools for Predicting Common Bile Duct Stones in Acute Cholecystitis Patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Keun Soo","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Surgery, Keimyung University Dongsan Medical Center Keimyung University School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Seok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine Seoul National University Bundang Hospital 166 Gumi\u2010ro, Bundang\u2010gu 463\u2010707 Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Seong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine Seoul National University Bundang Hospital 166 Gumi\u2010ro, Bundang\u2010gu 463\u2010707 Seongnam\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seoul National University College of Medicine Seoul National University Bundang Hospital 166 Gumi\u2010ro, Bundang\u2010gu 463\u2010707 Seongnam\u2010si Gyeonggi\u2010do 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