{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:18:39Z","timestamp":1792451919297,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue National Contre le Cancer","doi-asserted-by":"crossref","award":["1FI11687PIAE"],"award-info":[{"award-number":["1FI11687PIAE"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parathyroid glands (PGs) can be particularly hard to distinguish from surrounding tissue and thus can be damaged or removed during thyroidectomy. Postoperative hypoparathyroidism is the most common complication after thyroidectomy. Very recently, it has been found that the parathyroid tissue shows near\u2010infrared (NIR) auto\u2010fluorescence which could be used for intraoperative detection, without any use of contrast agents. The work described here presents a histological validation ex vivo of the NIR imaging procedure and evaluates intraoperative PG detection by NIR auto\u2010fluorescence using for the first time to our knowledge a commercially available clinical NIR imaging device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ex vivo study on resected operative specimens combined with a prospective in vivo study of consecutive patients who underwent total or partial thyroid, or parathyroid surgery at a comprehensive cancer center. During surgery, any tissue suspected to be a potential PG by the surgeon was imaged with the Fluobeam 800\n                      <jats:sup>\u00ae<\/jats:sup>\n                      system. NIR imaging was compared to conventional histology (ex vivo) and\/or visual identification by the surgeon (in vivo).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We have validated NIR auto\u2010fluorescence with an ex vivo study including 28 specimens. Sensitivity and specificity were 94.1 and 80 %, respectively. Intraoperative NIR imaging was performed in 35 patients and 81 parathyroids were identified. In 80\/81 cases, the fluorescence signal was subjectively obvious on real\u2010time visualization. We determined that PG fluorescence is 2.93 \u00b1 1.59 times greater than thyroid fluorescence in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010time NIR imaging based on parathyroid auto\u2010fluorescence is fast, safe, and non\u2010invasive and shows very encouraging results, for intraoperative parathyroid identification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-016-3571-5","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T21:02:45Z","timestamp":1464123765000},"page":"2131-2138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Intraoperative Near\u2010infrared Imaging for Parathyroid Gland Identification by Auto\u2010fluorescence: A Feasibility 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