{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:44:45Z","timestamp":1785793485682,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation (NRF) of Korea","award":["NRF-2015R1A2A2A01005153"],"award-info":[{"award-number":["NRF-2015R1A2A2A01005153"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic lidocaine has analgesic and anti\u2010inflammatory effects. The purpose of this prospective, randomized, double\u2010blind study was to evaluate the effects of intravenous lidocaine on pain following thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight adult patients scheduled for total thyroidectomy were randomly allocated to receive a 1.5\u00a0mg\/kg lidocaine bolus followed by a 2\u00a0mg\/kg\/h infusion during surgery, or the same volume of normal saline (control). After thyroidectomy, we evaluated postoperative pain, nausea, fentanyl consumption, frequency of pushing the button (FPB) for patient\u2010controlled analgesia (PCA), High\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) in serum, and patient satisfaction scores regarding the recovery process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative pain and nausea scores were significantly lower in the lidocaine group for the first 4 h following thyroidectomy, compared to the control group. Fentanyl consumption and FPB for the PCA were also significantly reduced in the lidocaine group for 4 h following thyroidectomy, and hs\u2010CRP was significantly less in the lidocaine group at postoperative days 1 and 3. Furthermore, satisfaction scores were significantly higher in the lidocaine group compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous lidocaine effectively reduced postoperative pain and nausea following thyroidectomy as well as improved the quality of recovery. Trial registration number: Clinicaltrials.gov NCT01608360.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3619-6","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T16:39:00Z","timestamp":1467736740000},"page":"2941-2947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double\u2010Blind, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"40","author":[{"given":"Geun Joo","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Inje University Seoul Paik Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong In","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Wha","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Chung\u2010Ang University College of Medicine 84 Heukseok\u2010ro, Dongjak\u2010gu 06911 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200009000\u201000038"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(99)00268\u20107"},{"key":"e_1_2_7_4_2","first-page":"Cd009642","article-title":"Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery","volume":"7","author":"Kranke P","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010199812000\u201000011"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/77.4.463"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109472\u20105"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952\u20108180(97)00069\u2010X"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109582"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0259\u20101162.156292"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010012\u20102557\u20102"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010015\u20100026\u20108"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.08.062"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000346612"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael217"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181bab1bd"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(95)00186\u20107"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010015\u20103105\u20106"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010200203000\u201000019"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010011\u20109619\u2010y"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102044.2012.07295.x"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3619-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-016-3619-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3619-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-016-3619-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T16:38:22Z","timestamp":1703608702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-016-3619-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1007\/s00268-016-3619-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-016-3619-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}