{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:36:12Z","timestamp":1771029372477,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>To retrospectively create a predictive score for estimating amputation\u2010free survival (AFS) in patients with critical limb ischemia (CLI) operated on with the use of a heparin\u2010bonded expanded polytetrafluoroethylene (ePTFE) bypass graft (Hb\u2010ePTFE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over a 13\u2010year period, ending in March 2015, a Hb\u2010ePTFE graft was implanted in 683 patients undergoing below\u2010knee revascularization for CLI in seven Italian vascular hospitals. Data concerning these interventions were retrospectively collected in a multicenter registry with a dedicated database. Univariate and multivariable analyses with Kaplan\u2013Meier estimates were used to identify potential significant predictors of AFS at 5 years, and then a predictive risk score was constructed. A qualitative assessment of the Kaplan\u2013Meier survival estimates for each integer score was performed, and subgroups of risk were stratified on the basis of the primary end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, estimated 5\u2010year AFS rate was 48.3 % (SE 0.024). At multivariate analysis, older age, coronary artery disease, end\u2010stage renal disease, tissue loss and poor runoff score were predictors of AFS. The integer score ranged from 0 to 11; Kaplan\u2013Meier analysis for AFS in each score group identified three subgroups with significant differences at 5 years: low\u2010risk subgroup (scores from 0 to 2, 67.7 %), medium\u2010risk subgroup (scores 3 and 4, 49.2 %, <jats:italic>p<\/jats:italic> &lt; 0.001\u00a0in comparison with low\u2010risk subgroup) and high\u2010risk subgroup (scores from 5 to 11, 25.2 %, <jats:italic>p<\/jats:italic> &lt; 0.001\u00a0in comparison with either low\u2010risk subgroup or medium\u2010risk subgroup).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A category of low\u2010risk patients with CLI treated with the indexed graft does exist, thus suggesting a primary role for Hb\u2010ePTFE in such patients. A prospective validation of such a score is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3674-z","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T13:07:40Z","timestamp":1469797660000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Multicenter Predictive Score for Amputation\u2010Free Survival for Patients Operated on with an Heparin\u2010Bonded ePTFE Graft for Critical Limb Ischemia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-5961","authenticated-orcid":false,"given":"Walter","family":"Dorigo","sequence":"first","affiliation":[{"name":"Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, Careggi University Teaching Hospital University of Florence School of Medicine Largo Brambilla, 3 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Piffaretti","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Department of Surgery and Morphological Sciences, Circolo University Teaching Hospital University of Insubria School of Medicine Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Pulli","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Department of Cardiothoracic Surgery University of Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Castelli","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Department of Surgery and Morphological Sciences, Circolo University Teaching Hospital University of Insubria School of Medicine Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, Careggi University Teaching Hospital University of Florence School of Medicine Largo Brambilla, 3 50134 Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PROPATEN Italian Registry Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Pratesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Dorigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Pulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Alessi Innocenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pratesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"De Blasis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Scalisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Monaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Dorrucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Vecchiati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Casali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiore","family":"Ferilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Ottavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Piffaretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Franchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.03.281"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.035"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.05.114"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.01.037"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.11.053"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.03.031"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.08.065"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.11.107"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.10.104"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2009.10.002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.05.046"},{"issue":"2","key":"e_1_2_7_13_2","first-page":"187","article-title":"Results from an Italian multicentric registry comparing heparin\u2010bonded ePTFE graft and autologous saphenous vein in below\u2010knee femoro\u2010popliteal bypasses","volume":"53","author":"Dorigo W","year":"2012","journal-title":"J Cardiovasc Surg"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.07.062"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741\u20105214(97)70045\u20104"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199510000\u201000003"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1998.00765.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.108634"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.125"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.04.014"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.05.006"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200103000\u201000021"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.09.083"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.07.065"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.12.042"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.01.027"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.003"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.4.452"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3674-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-016-3674-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-016-3674-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3674-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T16:50:32Z","timestamp":1703609432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-016-3674-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,29]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1007\/s00268-016-3674-z"],"URL":"https:\/\/doi.org\/10.1007\/s00268-016-3674-z","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,29]]}}}