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Benefits and safety in the use of sedative agents after abdominal operations to improve recovery are not well known. The present study is to evaluate the efficacy and safety of dexmedetomidine use in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective randomized controlled trial of 145 patients undergoing abdominal operations was conducted in the Surgical Intensive Care Unit of Jinling Hospital between October and December 2015. Thirty\u2010two patients were excluded, and 113 were included and divided into the experimental group (59 patients) receiving dexmedetomidine and analgesics for 72 h after abdominal operations, and the control group (54 patients) receiving only analgesics. Postoperative pain, inflammatory response, recovery of gastrointestinal function, adverse events, and sedation level were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain scores, assessed by Prince Henry Pain Scale (PHPS), in the experimental group were significantly lower than in the control group on the first (1.53 vs. 2.07, <jats:italic>p<\/jats:italic> \u2264 0.01), second (1.07 vs. 1.63, <jats:italic>p<\/jats:italic> \u2264 0.01), and third day (1.08 vs. 1.82, <jats:italic>p<\/jats:italic> = 0.01). Time to defecation was 0.60\u00a0days shorter in the experimental group than the control group (2.51 vs. 3.11<jats:italic>, p<\/jats:italic> = 0.01). There was no significant difference between inflammatory responses in the two groups (<jats:italic>p<\/jats:italic> &gt; 0.05). Both groups had similar blood pressure, heart rate, prevalence of bradycardia, and hypotension requiring interventions (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of dexmedetomidine to analgesia after abdominal operations is safe and could enhance gastrointestinal function recovery and pain control when monitored carefully. The capacity of dexmedetomidine to attenuate inflammatory responses requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3698-4","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T22:20:27Z","timestamp":1472854827000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Addition of Dexmedetomidine to Analgesia for Patients After Abdominal Operations: A Prospective Randomized Clinical Trial"],"prefix":"10.1002","volume":"41","author":[{"given":"Minhua","family":"Cheng","sequence":"first","affiliation":[{"name":"Medical School of Nanjing University 22 Hankou Road Nanjing Jiangsu People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of General Surgery, Jinling Hospital Medical School of Nanjing University 305 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