{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:31:39Z","timestamp":1783607499927,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Parathyroid autotransplantation is an easy procedure with a low complication rate. We adopted the transplantation into the sternocleidomastoid muscle, which allows an easier and time\u2010saving surgical procedure using the same surgical incision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we retrospectively reviewed the records of 396 consecutive patients, who underwent total thyroidectomy for benign thyroid disease. In all cases in which a parathyroid was damaged or inadvertently removed, the gland was transplanted; before the autotransplantation, the parathyroid tissue was put in a cell culture nutrient solution for 5\u00a0min, afterward fragmented, and then was transplanted in the sternocleidomastoid muscle. To demonstrate a beneficial effect of the cell nutrient solution step, we compared data of transplanted patients with a control group of cases (<jats:italic>n<\/jats:italic> = 190) undergoing a standard immediate autotransplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We divided patients in two main groups: group A (<jats:italic>n<\/jats:italic> = 160) including subjects that underwent one or more parathyroid gland autotransplantation using the cell nutrient solution, and group B (<jats:italic>n<\/jats:italic> = 236) concerning those who were not transplanted. Among patients, 62 hypocalcemias occurred, 40\u00a0in the group A and 22\u00a0in the group B (<jats:italic>P<\/jats:italic> &lt; 0.001): 91.9 % were transient and 8.1 % (5 patients) definitive, all pertaining to the group B. Among controls (group C), 42 hypocalcemias occurred (<jats:italic>P<\/jats:italic> = 0.616 vs. group A and <jats:italic>P<\/jats:italic> = 0.002 vs. group B) and 3\/42 became definitive (<jats:italic>P<\/jats:italic> = 0.096 vs. group A and <jats:italic>P<\/jats:italic> = 0.121 vs. group B). All differences concerning pre\u2010 and postoperative calcium values were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We recommend the routine parathyroid autotransplantation, when a vascular damage is certain or suspected, in order to reduce the rate of permanent hypoparathyroidism, using a cell culture nutrient solution before gland transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3754-0","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T17:54:07Z","timestamp":1476294847000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Parathyroid Autotransplantation During Thyroid Surgery: A Novel Technique Using a Cell Culture Nutrient Solution"],"prefix":"10.1002","volume":"41","author":[{"given":"Fausto","family":"Fam\u00e0","sequence":"first","affiliation":[{"name":"Department of Human Pathology University Hospital of Messina Via Consolare Valeria, 1 98125 Messina Italy"},{"name":"Complesso MITO Residenza Ginestre F\/2 98151 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cicci\u00f9","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences, Morphological and Functional Images University Hospital of Messina Via Consolare Valeria, 1 98125 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Polito","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Messina Via Consolare Valeria, 1 98125 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cascio","sequence":"additional","affiliation":[{"name":"Department of Human Pathology University Hospital of Messina Via Consolare Valeria, 1 98125 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gioffr\u00e9\u2010Florio","sequence":"additional","affiliation":[{"name":"Department of Human Pathology University Hospital of Messina Via Consolare Valeria, 1 98125 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Piquard","sequence":"additional","affiliation":[{"name":"Department of General, Endocrine and Thoracic Surgery Regional Hospital of Orleans 14, Avenue de l\u2019Hopital 45067 Orl\u00e9ans (cedex 2) France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Saint\u2010Marc","sequence":"additional","affiliation":[{"name":"Department of General, Endocrine and Thoracic 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