{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:34Z","timestamp":1787066134557,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine the diagnostic accuracy of abdominal ultrasound (US) for the diagnosis of acute appendicitis (AA), in terms of sensitivity, specificity and post\u2010test probabilities for positive and negative result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of MEDLINE, Embase, The Cochrane library and Science Citation Index Expanded from January 1994 to October 2014 was performed. Two authors independently evaluated studies for inclusion, extracted data and performed analyses. The reference standard for evaluation of final diagnosis was pathohistological report on tissue obtained at appendectomy. Summary sensitivity, specificity and post\u2010test probability of AA after positive and negative result of US with corresponding 95% confidence intervals (CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 3306 references identified through electronic searches, 17 reports met the inclusion criteria, with 2841\u00a0included participants. The summary sensitivity and specificity of US for diagnosis of AA were 69% (95% CI 59\u201378%) and 81% (95% CI 73\u201388%), respectively. At the median pretest probability of AA of 76.4%, the post\u2010test probability for a positive and negative result of US was 92% (95% CI 88\u201395%) and 55% (95% CI 46\u201363%), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abdominal ultrasound does not seem to have a role in the diagnostic pathway for diagnosis of AA in suspected patients. The summary sensitivity and specificity of US do not exceed that of physical examination. Patients that require additional diagnostic workup should be referred to more sensitive and specific diagnostic procedures, such as computed tomography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-016-3792-7","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T13:42:53Z","timestamp":1479476573000},"page":"693-700","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Diagnostic Accuracy of Abdominal Ultrasound for Diagnosis of Acute Appendicitis: Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1719-0424","authenticated-orcid":false,"given":"Vanja","family":"Giljaca","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University Hospital Centre Rijeka Kresimirova 42 51000 Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Nadarevic","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Centre Rijeka Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Poropat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University Hospital Centre Rijeka Kresimirova 42 51000 Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna Stefanac","family":"Nadarevic","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of Rijeka School of Medicine Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Stimac","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University Hospital Centre Rijeka Kresimirova 42 51000 Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.233.9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736\u20104679(01)00353\u20105"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115734"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.5.556"},{"key":"e_1_2_5_6_2","first-page":"11","article-title":"Assessment of peritonism in appendicitis","volume":"78","author":"Golledge J","year":"1996","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_5_7_2","first-page":"46","article-title":"The value of history taking, physical examination in the study of acute appendicitis in comparison to histopathology","volume":"5","author":"Abdul Rahman MM","year":"2006","journal-title":"Iraqi Postgrad Med J"},{"key":"e_1_2_5_8_2","first-page":"227","article-title":"Accurate diagnosis of acute appendicitis: a retrospective and prospective analysis of 686 patients","volume":"158","author":"Izbicki JR","year":"1992","journal-title":"Eur J Surg"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198411000\u201000002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20109\u2010139"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2009.10.004"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20241"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.26719\/2012.18.1.66"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1865\u20101380\u20105\u201026"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102247"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121753"},{"key":"e_1_2_5_17_2","first-page":"83","article-title":"US or CT for diagnosis of appendicitis in children and adults? A meta\u2010analysis","volume":"24","author":"Moineddin DAS","year":"2006","journal-title":"Radiology"},{"key":"e_1_2_5_18_2","first-page":"CD008359","article-title":"Appendectomy versus antibiotic treatment for acute appendicitis","volume":"11","author":"Wilms IM","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_19_2","first-page":"96","article-title":"Clinical judgment remains of great value in the diagnosis of acute appendicitis","volume":"49","author":"Bergeron E","year":"2006","journal-title":"Can J Surg"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1748"},{"key":"e_1_2_5_21_2","first-page":"CD001546","article-title":"Laparoscopic versus open surgery for suspected appendicitis","volume":"4","author":"Sauerland S","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000103071.35986.c1"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200104000\u201000001"},{"key":"e_1_2_5_24_2","first-page":"553","article-title":"Malpractice claims relating to the diagnosis and treatment of acute appendicitis\u2010decisions of the Norddeutsche Schlichtungsstelle (Expert Panel for Extrajudicial Claims Resolution of the Medical Associations in Northern Germany)","volume":"101","author":"Vinz H","year":"2007","journal-title":"Z Arztl Fortbild Qualitatssich"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010155\u20108\u2010201110180\u201000009"},{"key":"e_1_2_5_26_2","volume-title":"Version 5.2","author":"Review Manager (RevMan) [Computer Program]","year":"2012"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"e_1_2_5_28_2","unstructured":"TakwoingiY DeeksJJ(2015)MetaDAS: a SAS macro for meta\u2010analysis of diagnostic accuracy studies version 1.3.http:\/\/srdta.cochrane.org\/sites\/srdta.cochrane.org\/files\/uploads\/METADAS_v1.3_txt.txt. Accessed on 15 Jan 2015"},{"key":"e_1_2_5_29_2","volume-title":"Version 9.2","author":"SAS 9.2 [Computer Program]. SAS E","year":"2008"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6717"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2251011780"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445\u20102197.2002.02548.x"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.04.039"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2011.82195"},{"key":"e_1_2_5_35_2","first-page":"1165","article-title":"Ultrasonography in the diagnosis of acute appendicitis","volume":"76","author":"Grodzi\u0144ski T","year":"2004","journal-title":"Pol Przegl Chir"},{"key":"e_1_2_5_36_2","first-page":"144","article-title":"Avoiding negative appendectomies in rural surgical practice: is C\u2010reactive protein estimation useful as a diagnostic tool?","volume":"24","author":"John SK","year":"2011","journal-title":"Natl Med J India"},{"key":"e_1_2_5_37_2","first-page":"19","article-title":"Negative Appendectomy Rate: Can It Be Reduced?","volume":"8","author":"Khanzada TW","year":"2009","journal-title":"J Liaquat Uni Med Health Sci"},{"key":"e_1_2_5_38_2","first-page":"113","article-title":"The role of the Alvarado scoring system and ultrasonography in the diagnosis of acute appendicitis","volume":"20","author":"K\u00f6ksal H","year":"2009","journal-title":"Gazi Med. J."},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12262\u2010008\u20100035\u20107"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20107922\u20105\u20105"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u201069912011000200007"},{"key":"e_1_2_5_42_2","first-page":"138","article-title":"Role of abdominal sonography in the diagnosis of acute appendicitis","volume":"34","author":"Saeed K","year":"2009","journal-title":"Rawal Med J"},{"key":"e_1_2_5_43_2","first-page":"633","article-title":"Diagnostic value of ultrasonography in appendicitis","volume":"21","author":"Sezer TO","year":"2012","journal-title":"Adv Clin Exp Med"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12262\u2010007\u20100020\u20106"},{"key":"e_1_2_5_45_2","first-page":"216","article-title":"Assessment of the value of pelvic ultrasonography in pre\u2010menopausal women with right iliac fossa pain","volume":"101","author":"Stunell H","year":"2008","journal-title":"Ir Med J"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101003155"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0043\u201031442006000200007"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.10.004"},{"key":"e_1_2_5_49_2","first-page":"12","article-title":"Diagnostic accuracy of ultrasonography in acute appendicitis","volume":"26","author":"Hussain S","year":"2014","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.033"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2014.9.21568"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.11.010"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553\u20102712.1995.tb03606.x"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010141\u20107\u2010200410050\u201000011"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462305050488"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2005.6.4.267"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2411050913"},{"key":"e_1_2_5_58_2","first-page":"173","article-title":"Computed tomography and ultrasonography in the diagnosis of equivocal acute appendicitis","volume":"28","author":"Al\u2010Khayal KA","year":"2007","journal-title":"Saudi Med J"},{"key":"e_1_2_5_59_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2483071652"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.02.017"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3792-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-016-3792-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-016-3792-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-016-3792-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T11:50:47Z","timestamp":1704887447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-016-3792-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1007\/s00268-016-3792-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-016-3792-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]}}}