{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:55:33Z","timestamp":1790499333316,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc\u201099 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C\u201011\u00a0methionine positron emission tomography\/computed tomography (Met\u2010PET\/CT) is able to localise sestamibi\u2010negative hyperfunctioning parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 50 patients (38 females, 12\u00a0males, age 13\u201381 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met\u2010PET\/CT was performed before parathyroid surgery. The results of Met\u2010PET\/CT were analysed prospectively and compared with intraoperative and histopathological findings. 22% of the patients underwent previous parathyroid and\/or thyroid surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Met\u2010PET\/CT correctly located a single\u2010gland adenoma in 33 of 45 (73%) patients with pHPT. In 5 patients with multiglandular disease, Met\u2010PET\/CT detected at least one hyperfunctional parathyroid gland in 4 patients (80%). In 3 patients with double adenomas, 5 of 6 parathyroids were correctly located. Overall, 40 of 57 (70%) hyperfunctioning glands were identified with Met\u2010PET\/CT. Met\u2010PET\/CT was false\u2010negative in 12 of 50 (24%) patients and false\u2010positive in only one case (2%). Postoperatively, 48 of 50 patients (96%) were cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Additional pre\u2010interventional imaging with Met\u2010PET\/CT was able to identify hyperfunctioning parathyroid glands in 74% of patients with pHPT and negative sestamibi scans, thus enabling successful parathyroid surgery.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3795-4","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:43:03Z","timestamp":1478803383000},"page":"980-985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Is C\u201011\u00a0Methionine PET\/CT Able to Localise Sestamibi\u2010Negative Parathyroid Adenomas?"],"prefix":"10.1002","volume":"41","author":[{"given":"Theresia","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Katholisches Klinikum Mainz An der Goldgrube 11 55131 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Medical Center Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Schwenzer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Medical Center Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambros","family":"Beer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Medical Center Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Luster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Marburg Marburg 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