{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:56Z","timestamp":1791619016433,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A1A1002001"],"award-info":[{"award-number":["NRF\u20102014R1A1A1002001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"False"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2014R1A1A1002001"],"award-info":[{"award-number":["NRF-2014R1A1A1002001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of the systemic lidocaine on postoperative recovery has not been definitively investigated despite its analgesic efficacy after surgery. The aim of this randomized, double\u2010blinded, controlled study was to evaluate the effect of intravenously administered lidocaine on the quality of recovery and on acute and chronic postoperative pain after robot\u2010assisted thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety patients who were undergoing robotic thyroidectomy were randomly assigned to the lidocaine or the control groups. The patients received 2\u00a0mg\/kg of lidocaine followed by continuous infusions of 3\u00a0mg\/kg\/h of lidocaine (Group L) or the same volume of 0.9% normal saline (Group C) intravenously during anesthesia. The acute pain profiles and the quality of recovery, which was assessed using the quality of recovery\u201040 questionnaire (QoR\u201040), were evaluated for 2\u00a0days postoperatively. Chronic postsurgical pain (CPSP) and sensory disturbances at the surgical sites were evaluated 3\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The QoR\u201040 and pain scores that were assessed during the 2\u00a0days that followed surgery were largely comparable between the groups. However, CPSP was more prevalent in the Group C than in the Group L (16\/43 vs. 6\/41; <jats:italic>p<\/jats:italic> = 0.025). The tactile sensory score 3\u00a0months after the operation was significantly greater in the Group L than in the Group C (7 vs. 5; <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systemic lidocaine administration was associated with reductions in CPSP and sensory impairment after robot\u2010assisted thyroidectomy although it was not able to reduce acute postsurgical pain or improve the quality of recovery.<\/jats:p><jats:p><jats:italic>Trial registry number<\/jats:italic> NCT01907997 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">http:\/\/clinicaltrials.gov<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3842-1","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T16:55:30Z","timestamp":1480352130000},"page":"1305-1312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double\u2010Blinded, Controlled Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Kwan Woong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine National Health Insurance Service Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee\u2010Hyun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Surgery 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