{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:12:11Z","timestamp":1761581531728},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the role of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\u2010computed tomography (PET\u2010CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients with thymic epithelial tumors who underwent PET\u2010CT before and after induction therapy were retrospectively analyzed. The relationship between the change in the maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>) in PET\u2010CT, the response evaluation criteria in solid tumors and the pathologic response (Ef0, no necrosis of tumor cells; Ef1, some necrosis of tumor cells with more than one\u2010third of viable tumor cells; Ef2, less than one\u2010third of tumor cells were viable; and Ef3, no tumor cells were viable) was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort consisted of 5\u00a0males and 9 females. Nine of the patients had thymoma, and 5 had thymic carcinoma. The induction therapy included chemotherapy in 9 cases, chemoradiation therapy in 4 cases and radiation therapy in 1 case. Among the 8 patients with a pathologic response of Ef0\/1, 5 were clinically evaluated as having stable disease (SD), while 3 were found to have had a partial response (PR). The SUV<jats:sub>max<\/jats:sub> was elevated in 2 cases, unchanged in 1 and decreased in 5. On the other hand, 3 of the 6 patients with a pathologic response of Ef2, 3 were classified as having SD, while the other 3 had a PR. The SUV<jats:sub>max<\/jats:sub> decreased in all of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In comparison with CT, PET\u2010CT seems to be useful for predicting the pathologic response to induction therapy in patients with thymic epithelial tumors.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-3938-2","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T19:13:57Z","timestamp":1488827637000},"page":"1828-1833","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of <sup>18<\/sup>F\u2010fluorodeoxyglucose Positron Emission Tomography\u2010Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors"],"prefix":"10.1002","volume":"41","author":[{"given":"Koichi","family":"Fukumoto","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Okasaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Hakiri","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiological and Medical Laboratory Sciences Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho, Showa\u2010ku 466\u20108550 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748\u2010015\u20100590\u20103"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900043"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146195"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.154138"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101775\u2010x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13210"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.102"},{"key":"e_1_2_8_9_2","first-page":"475","article-title":"Which variables should be considered in patients with stage II and III non\u2010small cell lung cancer after neoadjuvant therapy?","volume":"77","author":"Ozeki N","year":"2015","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.3867"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.08.012"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010010\u20100455\u2010x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20102929"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19811201)48:11<2485::AID\u2010CNCR2820481123>3.0.CO;2\u2010R"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs527"},{"key":"e_1_2_8_17_2","first-page":"175","volume-title":"General rule for clinical and pathological record of lung cancer","author":"Japan Lung Cancer Society","year":"2003"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31802bafc8"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.08.008"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.02.018"},{"key":"e_1_2_8_21_2","first-page":"1165","article-title":"Positron emission tomography for predicting recurrence in stage I lung adenocarcinoma: standardized uptake value corrected by mean liver standardized uptake value","volume":"40","author":"Shiono S","year":"2011","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-017-3938-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-3938-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-3938-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-017-3938-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T17:06:40Z","timestamp":1704906400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-017-3938-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,6]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1007\/s00268-017-3938-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-017-3938-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,6]]}}}