{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:53:02Z","timestamp":1768726382145,"version":"3.49.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medical treatment is effective in the majority of patients with gastroesophageal reflux disease (GERD). Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but their effect is short\u2010lived. H2\u2010receptor antagonists and proton\u2010pump inhibitors provide more effective options for remission of GERD symptoms and healing of esophagitis. Prokinetic medications (e.g., metoclopramide) have not been proven to help in the control of symptoms. Baclofen, which inhibits transient lower esophageal sphincter relaxations, provide an additional option for patients with persistent symptoms related to GERD; however its use is limited by side effects. Long\u2010term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing.<\/jats:p>","DOI":"10.1007\/s00268-017-3954-2","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T19:02:53Z","timestamp":1490036573000},"page":"1678-1684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Medical Treatment of Gastroesophageal Reflux Disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Daniel A.","family":"Kroch","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine CB #7080 27599 Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan D.","family":"Madanick","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine CB #7080 27599 Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00630.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2003.07531.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04774.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.9.965"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04232.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2007.01348.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316854"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01798350"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054391"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750026326"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2006.04549.x"},{"key":"e_1_2_6_15_2","first-page":"635","article-title":"Twenty\u2010four\u2010hour pH measurements in morbid obesity: effects of massive overweight, weight loss and gastric distension","volume":"8","author":"Mathus\u2010Vliegen LM","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20279"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i28.4291"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/2327-6924.12133"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199957060\u201000003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391\u2010199508000\u201000006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509089680"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909093066"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308159"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2007.00650.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12640"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178061"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.046"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2006.02814.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.01.036"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12318"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dow020"},{"key":"e_1_2_6_32_2","unstructured":"IpS ChungM MoorthyD YuWW LeeJ ChanJA BonisPA LauJ(2011) Comparative effectiveness of management strategies for gastroesophageal reflux disease: update. Comparative Effectiveness Review No. 29. (Prepared by Tufts Medical Center Evidence\u2010based Practice Center under Contract No. HHSA 290\u20102007\u201010055\u2010I.) AHRQ Publication No. 11\u2010EHC049\u2010EF.Agency for Healthcare Research and Quality Rockville.www.effectivehealthcare.ahrq.gov\/reports\/final.cfm"},{"issue":"5","key":"e_1_2_6_33_2","first-page":"CD002095","article-title":"Short\u2010term treatment with proton pump inhibitors, H2\u2010receptor antagonists and prokinetics for gastro\u2010oesophageal reflux disease\u2010like symptoms and endoscopy negative reflux disease","volume":"31","author":"Sigterman KE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.013"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i26.4067"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010008\u20100466\u20109"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.1.13"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28649"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i11.1480"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.4.387"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04272.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2000.00829.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2006.02911.x"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542\u20103565(05)00860\u20108"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2000.00882.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2005.00518.x"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31876"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31814a4e5c"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.12.001"},{"key":"e_1_2_6_50_2","first-page":"55B","article-title":"Prokinetic therapy in gastroesophageal reflux disease","volume":"11","author":"Champion MC","year":"1997","journal-title":"Can J Gastroenterol"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307583"},{"issue":"9","key":"e_1_2_6_52_2","first-page":"1766","article-title":"Omeprazole versus ranitidine or ranitidine\/metoclopramide in poorly responsive symptomatic gastroesophageal reflux disease","volume":"91","author":"Richter JE","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2009.04189.x"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109667"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(88)80003\u20109"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04358.x"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04565.x"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20102980.2010.00418.x"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2002.01325.x"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.19"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2003.01394.x"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05068.x"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-017-3954-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-3954-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-3954-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-017-3954-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T17:06:05Z","timestamp":1704906365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-017-3954-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1007\/s00268-017-3954-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-017-3954-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,20]]}}}