{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:24:49Z","timestamp":1792290289073,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transarterial embolization of liver hemangiomas has not been considered to be consistently effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The charts of 25 patients who underwent superselective transarterial chemoembolization with the bleomycin\u2013lipiodol emulsion were evaluated retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients had abdominal pain; asymptomatic\/vaguely symptomatic enlargement was the treatment indication in three patients. A single session was conducted in 17 patients, two sessions in 7 and three sessions in one. After the first session, lesion volume decreased by median (range) 51% (10\u201392%) from median (range) 634 (226\u20138435) to 372(28\u20134710) cm<jats:sup>3<\/jats:sup> (<jats:italic>p<\/jats:italic> &lt; 0.01), after a median period of 4\u00a0months (range 2\u20138). A second session was performed in eight patients (median (range) initial volume 1276 (441\u20138435) cm<jats:sup>3<\/jats:sup>) with persistent complaints and\/or large lesions receiving feeders from both right and left hepatic arteries (staged treatment). Median (range) lesion size decreased further from 806 (245\u20134710) to 464 (159\u20132150) cm<jats:sup>3<\/jats:sup> (<jats:italic>p<\/jats:italic> &lt; 0.01). Three patients experienced a postembolization syndrome that persisted after the first week. Seventeen of the 22 symptomatic patients (77%) reported resolution or marked amelioration of complaints. Regrowth after initial regression was not observed during median (range) 14 (8\u201339) months of follow\u2010up (<jats:italic>n<\/jats:italic>:18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transarterial chemoembolization with the bleomycin\u2013lipiodol emulsion is a potential alternative to surgery for symptomatic\/enlarging liver hemangiomas. Volume reduction is universal, and symptom control is satisfactory. Centrally located and very large (&gt;1000\u00a0cm<jats:sup>3<\/jats:sup>) lesions may require two sessions.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4069-5","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T17:22:05Z","timestamp":1497979325000},"page":"2796-2803","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Superselective Transarterial Chemoembolization as an Alternative to Surgery in Symptomatic\/Enlarging Liver Hemangiomas"],"prefix":"10.1002","volume":"41","author":[{"given":"\u0130lgin","family":"\u00d6zden","sequence":"first","affiliation":[{"name":"Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Faculty of Medicine Istanbul University Millet Caddesi\u2010\u00c7apa\u2010\u015eehremini 34390 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Poyanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131lmaz","family":"\u00d6nal","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Aslan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcltekin","family":"Ho\u015f","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Faculty of Medicine Istanbul University Millet Caddesi\u2010\u00c7apa\u2010\u015eehremini 34390 Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Acuna\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20101\u20104377\u20101454\u20108.00079\u20105"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400290146027"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198810000\u201000004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840310"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(85)92142\u20107"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167\u20108140(93)90172\u20105"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.8.978"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(03)00420\u20104"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.08.006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010013\u20101904\u20101"},{"key":"e_1_2_6_12_2","first-page":"927","article-title":"Interventional treatment of huge hepatic cavernous hemangioma","volume":"113","author":"Cao X","year":"2000","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010003\u20102754\u20102"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.25788"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010013\u20100618\u2010y"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135158"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010015\u20100680\u2010y"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.155.6.2122671"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/1993\/76519"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20101947\u20104\u2010283"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2014.14270"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.04.033"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12291"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000268108"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010001\u20100007\u2010x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270\u2010002\u20102648\u20108"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg020"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21410"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.09.058"},{"key":"e_1_2_6_30_2","first-page":"6877","article-title":"Transcatheter arterial embolic therapies for hepatocellular carcinoma: a literature review","volume":"34","author":"Nishikawa H","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02577392"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199604000\u201000012"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000113"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17680"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-017-4069-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-4069-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-4069-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-017-4069-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T17:16:12Z","timestamp":1704906972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-017-4069-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1007\/s00268-017-4069-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-017-4069-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]}}}