{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:03:48Z","timestamp":1788545028759,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thromboembolic events following splenectomy are not uncommon. However, the role of thromboprophylaxis and risk factors for thrombosis, as well as the clinical course and outcomes, are not well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of individuals who underwent splenectomy between January 2006 and December 2015\u00a0in two university hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 297 patients underwent splenectomy [open splenectomy (<jats:italic>n<\/jats:italic> = 199), laparoscopic splenectomy (<jats:italic>n<\/jats:italic> = 98)]. Mechanical (thigh\u2010length pneumatic compression stockings) and pharmacologic thromboprophylaxis (40\u00a0mg enoxaparin daily, starting 12 h after surgery until discharge) was provided for all patients. One hundred and sixteen patients (39%) also received an extended thromboprophylaxis course of enoxaparin for 2\u20134 weeks after discharge. Twenty\u2010three patients (7.7%) experienced thrombotic complications following splenectomy, including 16 cases (5.4%) of portal\u2010splenic mesenteric venous thrombosis (PSMVT), 5 (1.7%) pulmonary embolism and 2 (0.7%) deep vein thrombosis. Longer operative time (mean operative time of 405 vs. 273\u00a0min, <jats:italic>P<\/jats:italic> = 0.03) was independently associated with PSMVT. Post\u2010splenectomy thrombocytosis was not associated with thrombosis (<jats:italic>P<\/jats:italic> = 0.41). The overall thrombosis rate was significantly lower in patients who received an extended thromboprophylaxis course following splenectomy (3.4 vs. 10.5%, <jats:italic>P<\/jats:italic> = 0.02). Complete resolution of thrombosis was observed in most cases (<jats:italic>n<\/jats:italic> = 20, 87.0%), with no recurrent thrombosis during a mean follow\u2010up of 38 \u00b1 25\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thromboembolic complications, mainly PSMVT, are common following splenectomy. Longer operative time was associated with thrombosis. Significantly lower rates of thrombosis were found in patients who received an extended thromboprophylaxis course.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4185-2","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T17:25:01Z","timestamp":1502731501000},"page":"675-681","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Thromboembolic Events Following Splenectomy: Risk Factors, Prevention, Management and Outcomes"],"prefix":"10.1002","volume":"42","author":[{"given":"Amihai","family":"Rottenstreich","sequence":"first","affiliation":[{"name":"Department of Hematology Hadassah\u2010Hebrew University Medical Center POB 12000 91120 Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geffen","family":"Kleinstern","sequence":"additional","affiliation":[{"name":"Braun School of Public Health and Community Medicine Faculty of Medicine of the 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