{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:52:50Z","timestamp":1783000370727,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the impact of the location of esophagogastrostomy on acid and duodenogastroesophageal reflux (DGER) in patients undergoing gastric tube reconstruction and intrathoracic esophagogastrostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients receiving transthoracic esophagectomy without cervical lymph node dissection and gastric tube reconstruction by intrathoracic anastomosis were enrolled. All patients underwent 24\u2010h pH and bilirubin monitoring and gastrointestinal endoscopy one year after surgery. Patients were divided into three groups according to esophagogastrostomy location: group A (<jats:italic>n<\/jats:italic> = 9), above the top of the aortic arch; group B (<jats:italic>n<\/jats:italic> = 15), between the top and bottom of the aortic arch; and group C (<jats:italic>n<\/jats:italic> = 6), below the bottom of the aortic arch. The relations among the esophagogastrostomy location, 24\u2010h pH and bilirubin monitoring results, endoscopic findings, and reflux symptoms were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No acid reflux into the remnant esophagus was observed in group A, whereas it was observed in three of 15 patients (20%) in group B and in two of six patients (33%) in group C (<jats:italic>P<\/jats:italic> = 0.139). No DGER was found in group A, whereas DGER was observed in eight (53%) patients in group B and all patients in group C (<jats:italic>P<\/jats:italic> &lt; 0.001). Reflux esophagitis was observed in one patient (11%) in group A, five patients (33%) in group B, and all patients in group C (<jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In gastric tube reconstruction via intrathoracic anastomosis, esophagogastrostomy should be performed above the top of the aortic arch to prevent postoperative DGER and reduce the incidence of reflux esophagitis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4186-1","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T15:29:15Z","timestamp":1502724555000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Impact of the Location of Esophagogastrostomy on Acid and Duodenogastroesophageal Reflux After Transthoracic Esophagectomy with Gastric Tube Reconstruction and Intrathoracic Esophagogastrostomy"],"prefix":"10.1002","volume":"42","author":[{"given":"Hiroaki","family":"Usui","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Itatsu","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Funasaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine 65 Tsurumai\u2010cho 466\u20108550 Showa\u2010Ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"issue":"825","key":"e_1_2_5_2_2","first-page":"1","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma","volume":"340","author":"Lagergren J","year":"1999","journal-title":"The N Engl J Med"},{"issue":"580","key":"e_1_2_5_3_2","first-page":"3","article-title":"High incidence of reflux esophagitis observed by routine endoscopic examination after gastric pull\u2010up esophagectomy","volume":"27","author":"Shibuya S","year":"2003","journal-title":"World J 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