{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:43Z","timestamp":1786979923290,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Role of 18\u2010FDG PET\/CT had been well established in other more prevalent malignancies such as colorectal and lung cancer; however, this is not as well defined in cholangiocarcinoma. Literature focusing on the prognostic values of preoperative PET\/CT for resectable cholangiocarcinoma is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is a retrospective cohort of 66 consecutive patients who had received curative resection for cholangiocarcinoma from 2010 to 2015. All patients had preoperative 18\u2010FDG PET\/CT performed. Accuracy of metastatic lymph node detection of PET\/CT and the prognostic value of maximum standard uptake value (SUV\u2010max) was explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 38\u00a0male and 28 female recruited, and the median age was 66. Intrahepatic cholangiocarcinoma (ICC) constituted the majority (59.1%) of the cases, followed by hilar cholangiocarcinoma (22.8%), gallbladder cancer (13.6%) and common bile duct cancer (4.5%). The 3\u2010year disease\u2010free survival (DFS) and overall survival (OS) of the whole population were 27.1 and 39.2%, respectively. The median follow\u2010up duration was 27\u00a0months. The accuracy of PET\/CT in metastatic lymph node detection was 72.7% (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005, 95% CI 0.583\u20130.871) and 81.8% (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011, 95% CI 0.635\u20130.990) in whole population and ICC subgroup analysis, respectively. SUV\u2010max was shown by multivariate analysis to be an independent factor for DFS (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007 OR 1.16, 95% CI 1.04\u20131.29) and OS (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.012 OR 1.145, 95% CI 1.030\u20131.273) after resection. SUV\u2010max of 8 was shown to be a discriminant cut\u2010off for poor oncological outcomes in patients with early cholangiocarcinoma (TNM stage I or II) after curative resection (3\u2010year DFS: 21.2 vs. 63.2%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004, and 3\u2010year OS: 29 vs. 74%\n                      <jats:italic>P<\/jats:italic>\n                      = 0.048, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PET\/CT is a reliable imaging modality for metastatic lymph node detection in cholangiocarcinoma. Tumour SUV\u2010max is an independent factor for oncological outcomes in patients with resectable disease. For patients who have TNM stage I or II cholangiocarcinoma, tumour SUV\u2010max over 8 is associated with significantly inferior disease\u2010free and overall survival even after curative resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-017-4192-3","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T10:43:26Z","timestamp":1505299406000},"page":"823-834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Diagnostic and Prognostic Role of 18\u2010FDG PET\/CT in the Management of Resectable Biliary Tract Cancer"],"prefix":"10.1002","volume":"42","author":[{"given":"Ka Wing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Hong Kong, Queen Mary Hospital 102 Pokfulam Road Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan 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