{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:43:12Z","timestamp":1761896592889},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Historically, the benefit of liver resection for non\u2010colorectal, non\u2010neuroendocrine (NCNN) liver metastases has been controversial. This study aims to determine the preoperative prognostic factors of liver resection for NCNN liver metastases and validate the Adam score in an Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent liver resection for NCNN liver metastases were identified retrospectively from a prospective liver resection database of the single institution between 2001 and 2014. Univariate Cox regression models were used to identify associations with outcome variables. Recurrence\u2010free interval and overall survival were determined using the Kaplan\u2013Meier method and compared using log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight consecutive patients were identified, which met the study criteria. Univariate analysis demonstrated that adenocarcinoma histology of primary cancer, disease\u2010free interval and number of nodules were significant predictors of survival. Four of the six components of Adam score were significant predictors of survival. These were the presence of extrahepatic metastases, R2 resection, disease\u2010free interval and type of a primary tumour. The total Adam score was also a significant predictor of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver resection for NCNN liver metastases is a safe and viable treatment option in carefully selected patients. Significant preoperative prognostic factors include adenocarcinoma primary tumours, disease\u2010free interval and number of nodules. The total Adam score was a good predictor of overall survival and can be used to risk stratify patients undergoing hepatic resection for NCNN liver metastases.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4208-z","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T13:32:46Z","timestamp":1504618366000},"page":"1073-1084","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preoperative Prognostic Factors After Liver Resection for Non\u2010Colorectal, Non\u2010Neuroendocrine Liver Metastases and Validation of the Adam Score in an Asian Population"],"prefix":"10.1002","volume":"42","author":[{"given":"Dayna P. Y.","family":"Sim","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital 20 College Road 169856 Singapore Singapore"},{"name":"University of Glasgow Glasgow Scotland UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian K. P.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital 20 College Road 169856 Singapore Singapore"},{"name":"Duke NUS Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ser\u2010Yee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital 20 College Road 169856 Singapore Singapore"},{"name":"Duke NUS Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Yip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital 20 College Road 169856 Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain B. 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