{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:27:49Z","timestamp":1782253669227,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>\nSwallowing difficulties, the pathophysiology behind which is incompletely understood, have been reported in 47\u201383% of goiter patients referred for thyroidectomy. We aimed at examining the influence of thyroid surgery on swallowing symptoms and esophageal motility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three patients with benign nodular goiter undergoing thyroid surgery were included. All completed high\u2010resolution esophageal manometry examinations and the goiter symptom scale score, assessed by the thyroid\u2010specific patient\u2010reported outcome measure. The evaluations were performed before and 6\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before surgery, the goiter symptom score was median 39 points (range 2\u201361), which improved to median five points (range 1\u201352) after surgery (<jats:italic>p<\/jats:italic> &lt; 0.001). The motility parameters were within the limits of normal swallowing physiology, both before and after surgery. Only the upper esophageal sphincter (UES) pressure increased significantly from 70.6 \u00b1 27.7 to 87.7 \u00b1 43.2\u00a0mmHg after surgery (<jats:italic>p<\/jats:italic> = 0.04). Using regression analyses, there was no significant correlation between change in goiter symptoms and weight of the removed goiter, motility parameters, or motility disturbances. However, patients undergoing total thyroidectomy experienced a larger reduction in pressure in the area of the UES and former thyroid gland after surgery in comparison with patients undergoing less extensive surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Goiter symptoms improved significantly after thyroidectomy, but without correlation to esophageal motility disturbances. This information is essential when interpreting dysphagia in patients with nodular goiter, and when balancing patients\u2019 expectations to surgical goiter therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration number:<\/jats:title><jats:p>NCT03100357 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.org\">www.clinicaltrials.org<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4247-5","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T17:12:10Z","timestamp":1507741930000},"page":"998-1004","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in Swallowing Symptoms and Esophageal Motility After Thyroid Surgery: A Prospective Cohort Study"],"prefix":"10.1002","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct03100357","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jesper Roed","family":"Sorensen","sequence":"first","affiliation":[{"name":"Department of ORL Head &amp; Neck Surgery Odense University Hospital J.B. 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