{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:51:24Z","timestamp":1761562284247},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Complete macroscopic resection surgery, pleurectomy and decortication (PD) improve survival in selected patients with malignant pleural mesothelioma (MPM). Yet its value has been questioned because of concern that this extensive surgical procedure may disrupt health\u2010related quality of life (HRQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HRQoL was studied in patients undergoing PD surgery for MPM using EORTC QLQ\u2010C30\u00a0instrument at baseline (prior to surgery), 1, 4\u20135, 7\u20138, and 10\u201311\u00a0months following surgery. Global health and variables in function and symptom domains were investigated. Sub\u2010groups analyses were performed for ECOG performance status (PS), histological sub\u2010types and pathological tumor volume (pTV). Within\u2010patient comparisons to baseline scores were made using Wilcoxon signed\u2010rank test. Trends over time were evaluated using Cuzick\u2019s nonparametric test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 114 patients with median age of 70 years (range: 50\u201388) and PS 0: 35 (30.7%), epithelioid histology: 61 (53.5%) and volume &lt;600\u00a0ml: 58 (50.9%). Patients with good PS (PS 0), epithelioid histology and small pTV had greater level of functioning and were less symptomatic at baseline. Overall global health worsened at the first postoperative month (<jats:italic>p<\/jats:italic> = 0.0005) with subsequent improvement. Non\u2010epithelioid histology and patients with large pTV demonstrated greater improvement in global health, function and symptoms domains following a PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At baseline, the overall health\u2010related quality of life, function and symptom domains were adversely affected in non\u2010epithelioid histology and patients with large pTV. However, greatest improvement in global health, symptom and function domains were observed first month after PD and during the follow\u2010up in these sub\u2010groups.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4264-4","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T15:51:37Z","timestamp":1506354697000},"page":"1036-1045","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Influence of Pleurectomy and Decortication in Health\u2010Related Quality of Life Among Patients with Malignant Pleural Mesothelioma"],"prefix":"10.1002","volume":"42","author":[{"given":"Wickii T.","family":"Vigneswaran","sequence":"first","affiliation":[{"name":"Section of Cardiac and Thoracic Surgery, Department of Surgery University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"},{"name":"Department of Thoracic and Cardiovascular Surgery Loyola University Medical Center 2160 S First Avenue, (Bdg110, Suite 6256) 60153 Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Y.","family":"Kircheva","sequence":"additional","affiliation":[{"name":"Section of Cardiac and Thoracic Surgery, Department of Surgery University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"},{"name":"Department of Thoracic and Cardiovascular Surgery Loyola University Medical Center 2160 S First Avenue, (Bdg110, Suite 6256) 60153 Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian E.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Loyola University Medical Center 2160 S First Avenue, (Bdg110, Suite 6256) 60153 Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydeaka","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy Durkin","family":"Celauro","sequence":"additional","affiliation":[{"name":"Section of Cardiac and Thoracic Surgery, Department of Surgery University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berkley","family":"Rose","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology, Department of Medicine University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedy L.","family":"Kindler","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology, Department of Medicine University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya N.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Medicine 5841 S Maryland Ave 60637 Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"issue":"253","key":"e_1_2_5_2_2","first-page":"261","article-title":"Immunohistochemistry and molecular diagnostics of pleural malignant mesothelioma","volume":"136","author":"Betta PG","year":"2012","journal-title":"Arch Pathol Lab Med"},{"volume-title":"Atlas of tumor pathology. 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