{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:05:32Z","timestamp":1765713932296},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative ileus (POI) is observed in 20\u201330% of patients undergoing colorectal cancer surgery, despite enhanced recovery programs (ERPs). Cyclooxygenase (COX)\u20102 is identified as a key enzyme in POI, but other arachidonic acid pathway enzymes have received little attention despite their potential as selective targets to prevent POI. The objectives were to compare the expression of arachidonic acid metabolism (AAM) enzymes (1) between patients who underwent colorectal cancer surgery and followed an ERP or not (NERP), (2) and between ERP patients who experimented POI or not and (3) to determine the ability of antagonists of these pathways to modulate contractile activity of colonic muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a translational study. Main outcome measures were gastrointestinal motility recovery data, <jats:italic>mRNA<\/jats:italic> expressions of key enzymes involved in AAM (RT\u2010qPCR) and ex vivo motility values of the circular colon muscle. Twenty\u2010eight prospectively included ERP patients were compared to eleven retrospectively included NERP patients that underwent colorectal cancer surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ERP reduced colonic mucosal COX\u20102, microsomal prostaglandin E synthase (mPGES1) and hematopoietic prostaglandin D synthase (HPGDS) <jats:italic>mRNA<\/jats:italic> expression. mPGES1 and HPGDS <jats:italic>mRNA<\/jats:italic> expression were significantly associated with ERP compliance (respectively, <jats:italic>r<\/jats:italic>2 = 0.25, <jats:italic>p<\/jats:italic> = 0.002 and <jats:italic>r<\/jats:italic>2 = 0.6, <jats:italic>p<\/jats:italic> &lt; 0.001). In <jats:italic>muscularis propria<\/jats:italic>, HPGDS <jats:italic>mRNA<\/jats:italic> expression was correlated with GI motility recovery (<jats:italic>p<\/jats:italic> = 0.002). The pharmacological inhibition of mPGES1\u00a0increased spontaneous ex vivo contractile activity in circular muscle (<jats:italic>p<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effects of ERP on GI recovery are correlated with the compliance of ERP and could be mediated at least in part by mPGES1, HPGDS and COX\u20102. Furthermore, mPGES1 shows promise as a therapeutic target to further reduce POI duration among ERP patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4266-2","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T16:53:01Z","timestamp":1507222381000},"page":"953-964","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anti\u2010inflammatory Effects of Enhanced Recovery Programs on Early\u2010Stage Colorectal Cancer Surgery"],"prefix":"10.1002","volume":"42","author":[{"given":"Aur\u00e9lien","family":"Venara","sequence":"first","affiliation":[{"name":"TENS \u2010 The enteric nervous system in gut and brain disorders INSERM U1235 44093 Nantes France"},{"name":"L\u2019UNAM, University of Angers Angers France"},{"name":"Department of Digestive and Endocrinal Surgery University Hospital of Angers 4 rue Larrey 49933 Angers Cedex 9 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