{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:26Z","timestamp":1790713226258,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radioembolization (RE) with intra\u2010arterial administration of <jats:sup>90<\/jats:sup>Y microspheres is a promising technique for the treatment of liver metastases from small intestinal neuroendocrine tumors (SI\u2010NET) not amenable to surgery or local ablation. However, studies comparing RE to other loco\u2010regional therapies are lacking. The aim of this randomized study was to compare the therapeutic response and safety after RE and bland hepatic arterial embolization (HAE), and to investigate early therapy\u2010induced changes with diffusion\u2010weighted MRI (DWI\u2010MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients were included in a prospective randomized controlled pilot study, six assigned to RE and five to HAE. Response according to RECIST 1.1 using MRI or CT at 3 and 6\u00a0months post\u2010treatment was recorded as well as changes in DWI\u2010MRI parameters after 1\u00a0month. Data on biochemical tumor response, toxicity, and side effects were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three months after treatment, all patients in the HAE group showed partial response according to RECIST while none in the RE group did (<jats:italic>p<\/jats:italic> = 0.0022). After 6\u00a0months, the response rates were 4\/5 (80%) and 2\/6 (33%) in the HAE and RE groups, respectively (NS). DWI\u2010MRI metrics could not predict RECIST response, but lower pretreatment ADC<jats:sub>(120\u2013800)<\/jats:sub> and larger ADC<jats:sub>(0\u2013800)<\/jats:sub> increase at 1\u00a0month were related to larger decrease in tumor diameter when all tumors were counted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HAE resulted in significantly higher RECIST response after 3\u00a0months, but no difference compared to RE remained after 6\u00a0months. These preliminary findings indicate that HAE remains a safe option for the treatment of liver metastases from SI\u2010NET, and further studies are needed to establish the role of RE and the predictive value of MR\u2010DWI.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4324-9","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T16:20:03Z","timestamp":1511367603000},"page":"506-513","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Radioembolization Versus Bland Embolization for Hepatic Metastases from Small Intestinal Neuroendocrine Tumors: Short\u2010Term Results of a Randomized Clinical Trial"],"prefix":"10.1002","volume":"42","author":[{"given":"Anna\u2010Karin","family":"Elf","sequence":"first","affiliation":[{"name":"Department of Surgery, Sahlgrenska University Hospital and Sahlgrenska Academy University of Gothenburg Gothenburg 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