{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:37:56Z","timestamp":1782909476897,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients with primary aldosteronism (PA), adrenal venous sampling (AVS) is recommended to differentiate between unilateral (UNI) or bilateral (BIL) adrenal disease. A recent study suggested that lateralization could be predicted, based on the ratio of aldosterone\/cortisol levels (A\/C) between the left adrenal vein (LAV) and inferior vena cava (IVC), with a 100% positive predictive value (PPV). This study aimed to validate those findings utilizing a larger, multi\u2010institutional cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed of patients with PA who underwent AVS from 2 tertiary\u2010care institutions. Laterality was predicted by an A\/C ratio of &gt;3:1 between the dominant and non\u2010dominant adrenal. AVS results were compared to LAV\/IVC ratios utilizing the published criteria (Lt \u2265 5.5; Rt \u2264 0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 222 patients, 124 (57%) had UNI and 98 (43%) had BIL disease based on AVS. AVS and LAV\/IVC findings were concordant for laterality in 141 (64%) patients (69 UNI, 72 BIL). Using only the LAV\/IVC ratio, 54 (24%) patients with UNI disease on AVS who underwent successful surgery would have been assumed to have BAH unless AVS was repeated, and 24 (11%) patients with BIL disease on AVS may have been incorrectly offered surgery (PPV 70%). Based on median LAV\/IVC ratios (left 5.26; right 0.31; BIL 2.84), no LAV\/IVC ratio accurately predicted laterality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This multi\u2010institutional study of patients with both UNI and BIL PA failed to validate the previously reported PPV of LAV\/IVC ratio for lateralization. Caution should be used in interpreting incomplete AVS data to differentiate between UNI versus BIL disease and strong consideration given to repeat AVS prior to adrenalectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4327-6","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T17:19:15Z","timestamp":1510247955000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Multi\u2010institutional Comparison of Adrenal Venous Sampling in Patients with Primary Aldosteronism: Caution Advised if Successful Bilateral Adrenal Vein Sampling is Not Achieved"],"prefix":"10.1002","volume":"42","author":[{"given":"Tracy S.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin 9200 W. Wisconsin Avenue 53226 Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina W.","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin 9200 W. Wisconsin Avenue 53226 Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute for Health and Society Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute for Health and Society Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rilling","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"So","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Findling","sequence":"additional","affiliation":[{"name":"Endocrine Center and Clinics Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical College of Wisconsin 9200 W. Wisconsin Avenue 53226 Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of General Surgery and Surgical Oncology, Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20104061"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013\u20104146"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.168484"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010151\u20105\u2010200909010\u201000007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02097"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24182"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20102830"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(96)80033\u2010X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22374"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010008\u20109441\u20109"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.05.006"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010011\u20102121\u20105"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20103676"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12669"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.06.048"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.07.007"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12342"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12096"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.497"},{"key":"e_1_2_5_21_2","first-page":"1227","volume":"136","author":"Young WF","year":"2004","journal-title":"Role for adrenal venous sampling in primary aldosteronism Surgery"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-017-4327-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-4327-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-017-4327-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-017-4327-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T15:14:10Z","timestamp":1703603650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-017-4327-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1007\/s00268-017-4327-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-017-4327-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}