{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:06:54Z","timestamp":1766066814251},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether total parathyroidectomy (TPTX) or subtotal parathyroidectomy (SPTX) should be performed for primary hyperparathyroidism (PHPT) in patients with multiple endocrine neoplasia type 1 (MEN1) is controversial. At our institution, the parathyroidectomy strategy is based on the number of enlarged intraoperative parathyroid glands. We retrospectively analyzed our parathyroidectomy procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of PHPT treatment in patients with MEN1 who underwent parathyroidectomy from 1982 to 2012 at our department were retrospectively collected. The data were grouped according to the surgical procedure: TPTX, SPTX, and less than SPTX (LPTX). TPTX or SPTX was selected based on the preoperative examination findings and number of enlarged intraoperative parathyroid glands. The outcomes were the disease\u2010free survival (DFS) rate and postoperative calcium replacement rate based on Kaplan\u2013Meier analysis for each type of surgical procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were analyzed. The overall 5\u2010 and 10\u2010year DFS was 91.7 and 55.8%, respectively. The 5\u2010 and 10\u2010year DFS in each subgroup was 100.0 and 85.7% in the TPTX group, 89.4 and 57.3% in the SPTX group, and 91.6 and 57.3% in the LPTX group, respectively. The postoperative calcium replacement rate at 1 and 12\u00a0months was 91.7 and 58.3% in the TPTX group, 21.1 and 7.0% in the SPTX group, and 30.0 and 0.0% in the LPTX group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although LPTX was not satisfactory as a standard procedure, both SPTX and TPTX are effective treatment methods for PHPT in patients with MEN1. The parathyroidectomy strategy should be based on intraoperative evaluation of the parathyroid glands.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4366-z","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T15:06:35Z","timestamp":1510671995000},"page":"1772-1778","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of \u201cTailored\u201d Parathyroidectomy for Treatment of Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1"],"prefix":"10.1002","volume":"42","author":[{"given":"Kiyomi","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Haniu","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tokumitsu","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Omi","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho Shinjuku\u2010ku 162\u20108666 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"158","article-title":"Zur normalen und pathologischen Histologie der Glandula thyreoidea, parathyreoidea und Hypophysis","volume":"33","author":"Erdheim J","year":"1903","journal-title":"Beitrage zur path. 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