{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:25:49Z","timestamp":1759937149012,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gallstones are known to be associated with premalignant changes in the gallbladder epithelium that range from atypical hyperplasia, metaplasia, dysplasia to carcinoma. Recognition of factors associated with these changes in patients with gallstones can potentially be helpful in identifying patients to whom prophylactic cholecystectomy can be offered to reduce the chances of developing carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify factors associated with premalignant epithelial changes including atypical hyperplasia, metaplasia, and dysplasia in gallbladder mucosa in patients with chronic calculus cholecystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was retrospective case\u2013control study conducted over a period of 10 years from 2004 to 2014. Cases were patients with reported histopathological premalignant epithelial changes along with chronic calculus cholecystitis, and controls were patients without premalignant epithelial changes but chronic calculus cholecystitis. Controls were twice the number of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over study period, 92 patients were reported to have premalignant epithelial changes on gall bladder histopathology for whom 184 controls were selected. Of cases, 61 (66%) patients had atypical hyperplasia, while metaplasia and dysplasia were present in 26 (28%) and 5 (5%) cases, respectively. Mean age was 47.5 \u00b1 14.5 years, and 74% of the study population were female. Wall thickness of more than 3\u00a0mm (OR = 4.14, <jats:italic>p<\/jats:italic> value &lt; 0.001) turned out to be statistically significant independent variables associated with premalignant lesions in gallbladder mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Odds of premalignant epithelial change in gall bladder mucosa in patients with gall bladder wall thickness of more than 3\u00a0mm is four times the odds of patients with wall thickness less than 3\u00a0mm, and the effect is statistically significant. Prophylactic cholecystectomy should be considered for this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-017-4371-2","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T15:44:53Z","timestamp":1510760693000},"page":"1701-1705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors Associated with Premalignant Epithelial Changes in Chronic Calculous Cholecystitis: A Case\u2013Control Study"],"prefix":"10.1002","volume":"42","author":[{"given":"Muhibullah","family":"Bangash","sequence":"first","affiliation":[{"name":"Aga Khan University Hospital General Surgery Office, Link Building, Stadium Road 74800 Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rehman","family":"Alvi","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital General Surgery Office, Link Building, Stadium Road 74800 Karachi 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