{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:18:48Z","timestamp":1782602328821,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81572621"],"award-info":[{"award-number":["No. 81572621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572621"],"award-info":[{"award-number":["81572621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenal ganglioneuromas (AGNs) are extremely rare benign neoplasms. This study is to share our experience regarding diagnostic and operative management of these tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical details as well as follow\u2010up data were retrospectively analyzed in 42 primary AGN patients who received operative resection at a tertiary referral hospital in China between May 2005 and July 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients at diagnosis was 35.3 years (range 13\u201359 years). Among the patients, 28 were asymptomatic. The mean preoperative size was 5.3 \u00b1 2.2\u00a0cm (range 2.1\u201314.0\u00a0cm), and 17 cases were larger than 5\u00a0cm. All patients underwent operative resection as open adrenalectomy in 20 patients and laparoscopy in 22 patients. The mean tumor size on pathologic examination was 6.0 \u00b1 2.6\u00a0cm (range 2.2\u201317.0\u00a0cm). Laparoscopic operation showed its advantages over open surgery on the postoperative duration (5.0 vs. 7.3\u00a0days, <jats:italic>p<\/jats:italic> &lt; 0.001) and estimated blood loss (69.5 vs. 157.5\u00a0ml, <jats:italic>p<\/jats:italic> = 0.047). No patient had recurrence or metastasis during a median follow\u2010up of 70.5\u00a0months (range 3.7\u2013164.3\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe the largest AGN series reported to date. The preoperative diagnosis of AGN remains difficult despite of the progression of imaging examination. After complete resection, the prognosis of AGN patients is excellent. Laparoscopic approach has its advantages in the resection of AGNs.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4499-8","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T17:04:04Z","timestamp":1517331844000},"page":"2469-2475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population"],"prefix":"10.1002","volume":"42","author":[{"given":"Jing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Urology, Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Ruijin Second Road No. 197 200025 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Ruijin Second Road No. 197 200025 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010long","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Ruijin Second Road No. 197 200025 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010kang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Ruijin Second Road No. 197 200025 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,30]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"EnzingerFM WeissSW(1995)Ganglioneuroma. 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