{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:35:16Z","timestamp":1793345716360,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The equipment to detect indocyanine green (ICG) fluorescence for sentinel lymph node (SLN) biopsy in breast cancer is not widely accessible nor optimal. The fluorescence appears as a poorly defined white shine on a black background, and dimmed lighting is required. The aim of this study was to assess the feasibility, accuracy and healthcare costs of a novel approach for SLN biopsy by a video\u2010assisted ICG\u2010guided technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The technique for detecting SLN was radioisotope (RI) in 194 cases, video\u2010assisted ICG\u2010guided in 70 cases and a combined method in 71 cases. In the video\u2010assisted ICG group, a full HD laparoscopic system equipped with xenon lamps was used for a laser\u2010free detection of ICG within a colored and magnified high\u2010resolution image.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Detection of ICG fluorescence using a laparoscope with a near\u2010infrared filter provided a highly defined and colored image during SLN biopsy. SLN was identified in 100% of patients in all groups. Multiple SLNs were identified in 0.5% of RI patients, in 12.9% of ICG patients and in 14.1% of ICG + RI patients (<jats:italic>p<\/jats:italic> &lt; 0.0001). In ICG + RI group, 95.1% of lymph nodes were radioactive and 92.7% were fluorescent. Operative times and healthcare costs were equivalent between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Video\u2010assisted ICG\u2010guided technique is a feasible and surgeon\u2010friendly method for SLN biopsy, with equivalent efficacy compared to RI, providing an accurate staging of the axilla.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4534-9","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T18:16:11Z","timestamp":1517854571000},"page":"2815-2824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Novel Indocyanine Green Fluorescence\u2010Guided Video\u2010Assisted Technique for Sentinel Node Biopsy in Breast Cancer"],"prefix":"10.1002","volume":"42","author":[{"given":"Luca","family":"Sorrentino","sequence":"first","affiliation":[{"name":"Surgery Division, ASST Fatebenefratelli\u2010Sacco Luigi Sacco University Hospital via G. B. Grassi 74 20157 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Sartani","sequence":"additional","affiliation":[{"name":"Surgery Division, ASST Fatebenefratelli\u2010Sacco Luigi Sacco University Hospital via G. B. Grassi 74 20157 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Pietropaolo","sequence":"additional","affiliation":[{"name":"Surgery Division, ASST Fatebenefratelli\u2010Sacco Luigi Sacco University Hospital via G. B. Grassi 74 20157 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Bossi","sequence":"additional","affiliation":[{"name":"Surgery Department, Breast Unit ICS Maugeri S.p.A. 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