{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:39:56Z","timestamp":1788367196217,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shuang Ho Hospital, Taipei Medical University","award":["106SHHR02"],"award-info":[{"award-number":["106SHHR02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central neck dissection and total thyroidectomy are standard treatments for patients with papillary thyroid carcinoma (PTC) with clinically involved central nodes. However, prophylactic central neck dissection (pCND) in patients with clinically uninvolved cN0 has been beneficial in some studies but ineffective in others. We conducted a meta\u2010analysis to evaluate the efficacy and safety of pCND in patients with central neck lymph nodes cN0\u00a0PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed, EMBASE, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were electronically searched for studies published until September 2017. The meta\u2010analysis was conducted to calculate the pooled effect size by using random\u2010effects model. Treatment efficacies were measured by determining locoregional recurrence (LRR). Secondary outcomes included transient recurrent laryngeal nerve (RLN) injury, permanent RLN injury, transient hypocalcemia, and permanent hypocalcemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three retrospective and prospective cohort studies involving 18,376 patients were reviewed. Patients who underwent pCND had significantly lower LRR (odds ratio [OR] 0.65; 95% confidence interval [CI] 0.48\u20130.88) but significantly higher incidence rates of transient RLN injury (OR 2.03; 95% CI 1.32\u20133.13), transient hypocalcemia (OR 2.23; 95% CI 1.84\u20132.70), and permanent hypocalcemia (OR 2.22; 95% CI 1.58\u20133.13) than that of no pCND group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with no pCND, pCND significantly reduces LRR but is accompanied by numerous adverse effects. The clinical decision should be made after the shared decision\u2010making process of clinicians and patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4547-4","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T17:39:03Z","timestamp":1519753143000},"page":"2846-2857","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma with Clinically Uninvolved Central Neck Lymph Nodes: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"given":"Lawrence","family":"Chen","sequence":"first","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine Bradenton FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsiu","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"},{"name":"Comprehensive Cancer Center of Taipei Medical University Taipei Taiwan"},{"name":"Department of Laboratory Medicine, Shuang Ho Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010An","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan"},{"name":"Department of Surgery School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u2010Wui","family":"Loh","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Health Care, Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road, Zhonghe District 23561 New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u2010Wai","family":"Tam","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan"},{"name":"Department of Surgery School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for Evidence\u2010Based Health Care, Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road, Zhonghe District 23561 New Taipei City Taiwan"},{"name":"Cochrane Taiwan Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010006\u20109207\u20105"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20100285"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100418\u20103"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.003"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(94)90321\u20102"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21653"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2011.04162.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8985"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107819\u201012\u2010152"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.0786"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30360"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u2010191"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010016\u20105691\u20104"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1195"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2008.1.1.41"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010017\u20100438\u20108"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_9_22_2","first-page":"61","article-title":"Role of prophylactic central neck dissection in cN0 papillary thyroid cancer","volume":"29","author":"Costa S","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.01.113"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0011"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.09.019"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010011\u20101995\u20106"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010017\u20101556\u2010y"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.02.001"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010011\u20101833\u2010x"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/571480"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010008\u20100360\u20100"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.053"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.02.004"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.08.001"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20103825"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010015\u20100553\u20102"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.163"},{"key":"e_1_2_9_38_2","unstructured":"Marin ArteagaA PeloniG LeuchterIet al. Modification of the surgical strategy for the dissection of the recurrent laryngeal nerve using continuous intraoperative nerve monitoring.World J Surg(2017)10.1007\/s00268\u2010017\u20104277\u2010z"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-018-4547-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-018-4547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-018-4547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-018-4547-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:33:03Z","timestamp":1703633583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-018-4547-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,27]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1007\/s00268-018-4547-4"],"URL":"https:\/\/doi.org\/10.1007\/s00268-018-4547-4","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,27]]},"assertion":[{"value":"27 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}