{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:01:25Z","timestamp":1777615285396,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unit of Research, Education & Development, Region Ja\u0308mtland\/Ha\u0308rjedalen."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate whether patients presenting with laboratory results consistent with primary hyperparathyroidism (pHPT) are managed in accordance with guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The laboratory database at a hospital in Sweden, serving 127,000\u00a0inhabitants, was searched for patients with biochemically determined pHPT. During 2014, a total of 365 patients with biochemical laboratory tests consistent with pHPT were identified. Patients with possible differential diagnoses or other reasons for not being investigated according to international guidelines were excluded after scrutinizing records, after new blood tests, and clinical assessments by endocrine surgeons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 92 patients had been referred to specialists and 82 had not. The latter group had lower serum calcium (median 2.54\u00a0mmol\/L) and PTH (5.7 pmol\/L). Out of these 82 cases, 9 patients were diagnosed with pHPT or had some sort of long\u2010term follow\u2010up planned as outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary hyperparathyroidism is overlooked and underdiagnosed in a number of patients in the clinical setting. It is important to provide local guidelines for the management of patients presenting with mild pHPT to ensure that these patients receive proper evaluation and follow\u2010up according to current research.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4574-1","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T19:30:22Z","timestamp":1520883022000},"page":"2825-2834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary Hyperparathyroidism is Underdiagnosed and Suboptimally Treated in the Clinical Setting"],"prefix":"10.1002","volume":"42","author":[{"given":"Jacob","family":"Enell","sequence":"first","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Ume\u00e5 University 901 85 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham","family":"Bayadsi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Ume\u00e5 University 901 85 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University 751 85 Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Hennings","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Ume\u00e5 University 901 85 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/02813430600784443"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2008.03520.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010002\u20106621\u20100"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(97)90357\u20103"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1327.005"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067369"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.01.011"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006\u20102802"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.011"},{"key":"e_1_2_8_11_2","volume-title":"The parathyroids. 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