{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:58:55Z","timestamp":1792177135048,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cribriform\u2010morular variant of papillary thyroid carcinoma (CMV\u2010PTC) is rare; it may occur in cases of familial adenomatous polyposis (FAP) or be sporadic. To clarify the clinicopathological features of CMV\u2010PTC, the medical records of these patients were investigated retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Between 1979 and 2016, a total of 17,062 cases with PTC underwent initial surgery at Ito Hospital. Of these, 30 (0.2%) cases histologically diagnosed with CMV\u2010PTC were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The patients were all women, with a mean age at the time of surgery of 24 years. Seven (23%) cases were thought to have FAP because they had colonic polyposis or a family history of FAP or <jats:italic>APC<\/jats:italic> gene mutation. The remaining 23 (77%) were thought to be sporadic. Multiple tumors were detected in 6 cases, with a solitary tumor in 24. One patient had lung metastasis at diagnosis. Eleven patients underwent total thyroidectomy or subtotal thyroidectomy, and 19 underwent lobectomy. Twenty\u2010six (87%) patients underwent neck lymph node dissection. Three patients had tumor metastasis in central lymph nodes, but these were incidentally detected metastatic classical PTC (cPTC) based on histological examination. In this series, there were no cases of LN metastases of CMV\u2010PTC. During a mean follow\u2010up of 15 years, one patient had new cPTC in the remnant thyroid after initial surgery, and the other patients showed no signs of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CMV\u2010PTC occurred in young women, their long\u2010term prognosis was excellent. Total thyroidectomy is recommended for FAP\u2010associated CMV\u2010PTC, but modified neck lymph node dissection is not necessary.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4644-4","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T17:59:36Z","timestamp":1524679176000},"page":"3616-3623","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cribriform\u2010Morular Variant of Papillary Thyroid Carcinoma: Clinical and Pathological Features of 30 Cases"],"prefix":"10.1002","volume":"42","author":[{"given":"Junko","family":"Akaishi","sequence":"first","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology Yamanashi Hospital Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Ogimi","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi Y.","family":"Hames","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yabuta","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Tomoda","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Matsuzu","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Uruno","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ohkuwa","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuji","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Pathology Yamanashi Hospital Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery Ito Hospital 4\u20103\u20106, Jingumae, Shibuya\u2010ku 150\u20108308 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"123","article-title":"Multiple primary malignancies arising in the rectum, brain, and thyroid; 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