{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:48:54Z","timestamp":1769834934727,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although multidetector\u2010row computed tomography (MDCT) before biliary drainage is useful for the assessment of the resectability of perihilar cholangiocarcinoma (PHC), the impact of biliary drainage on MDCT images before surgical resection for PHC has been poorly studied, and its possible consequences for R0 resection of PHC remain unclear. This study was performed to compare the surgical outcomes of patients with PHC who underwent MDCT before versus after biliary drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive patients who underwent major hepatectomy extending to segment 1 with extrahepatic bile duct resection for PHC from 2009 to 2016 were retrospectively evaluated. R0 resection was defined as no residual cancer at all surgical margins. Patients with pathological stage IV PHC were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 142 patients who underwent major hepatectomy, 108 were eligible for this study. Of these 108 patients, 64 (59%) and 44 (41%) underwent MDCT before and after biliary drainage, respectively. The total bilirubin concentration at presentation was lower in patients who underwent MDCT before than after biliary drainage (4.1\u2009\u00b1\u20095.9 vs. 8.0\u2009\u00b1\u20097.1\u00a0mg\/ml, respectively; <jats:italic>p\u2009<\/jats:italic>=\u20090.002). Although there were no significant differences in the surgical characteristics or pathological stages between the two groups, R0 resection was more frequently achieved in patients who underwent MDCT before than after biliary drainage [46\/64 (72%) vs. 22\/44 (50%), respectively; <jats:italic>p\u2009<\/jats:italic>=\u20090.03]. On multivariate analysis, MDCT before biliary drainage was independently associated with R0 resection of PHC (risk ratio: 2.38, 95% CI 1.05\u20135.41; <jats:italic>p\u2009<\/jats:italic>=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In selected patients, MDCT should be performed before biliary drainage to achieve R0 resection of PHC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4654-2","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T16:14:24Z","timestamp":1526055264000},"page":"3676-3684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Biliary Drainage on Multidetector\u2010Row Computed Tomography on R0 Resection of Perihilar Cholangiocarcinoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Isamu","family":"Hosokawa","sequence":"first","affiliation":[{"name":"Department of General Surgery Chiba University Graduate School of Medicine 1\u20108\u20101 Inohana 260\u20100856 Chuo\u2010ku Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chiba University Graduate School of Medicine 1\u20108\u20101 Inohana 260\u20100856 Chuo\u2010ku Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Yoshitomi","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chiba University Graduate School of Medicine 1\u20108\u20101 Inohana 260\u20100856 Chuo\u2010ku Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chiba University Graduate School of Medicine 1\u20108\u20101 Inohana 260\u20100856 Chuo\u2010ku Chiba 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