{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:45:33Z","timestamp":1789688733534,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While carbohydrate loading is an important component of enhanced patient recovery after surgery, no study has evaluated the effects of preoperative carbohydrate loading after laparoscopic cholecystectomy (LC) on patient satisfaction and overall recovery. Thus, we aimed to investigate the impact of preoperative oral carbohydrates on scores from the quality of recovery 40\u2010item (QoR\u201040) questionnaire after LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 153 adults who underwent LC were randomized into three groups. Group MN\u2010NPO was fasted from midnight until surgery. Group No\u2010NPO received 400\u00a0mL of a carbohydrate beverage on the evening before surgery, and a morning dose of 400\u00a0mL was ingested at least 2 h before surgery. Group Placebo received the same quantity of flavored water as for group No\u2010NPO. The quality of recovery after general anesthesia was evaluated using QoR\u201040 questionnaire. Intraoperative hemodynamics were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences among the groups in terms of the pre\u2010 and postoperative global QoR\u201040 scores (<jats:italic>P<\/jats:italic>\u2009=\u20090.257). Group MN\u2010NPO had an elevated heart rate compared to patients who ingested a preoperative beverage (groups No\u2010NPO and Placebo; <jats:italic>P\u2009<\/jats:italic>=\u20090.0412).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preoperative carbohydrate beverage did not improve quality of recovery using the QoR\u201040 questionnaire after general anesthesia for laparoscopic cholecystectomy compared to placebo or conventional fasting. However, the preoperative fasting group had a consistently increased heart rate during changes in body position that induced hypotension, which is likely a result of depletion of effective intravascular volume caused by traditional fasting over 8 h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Clinical trial.gov identifier: NCT02555020.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-018-4717-4","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T17:13:31Z","timestamp":1529342011000},"page":"3150-3157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Preoperative Oral Carbohydrates on Quality of Recovery in Laparoscopic Cholecystectomy: A Randomized, Double Blind, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct02555020","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jeong Soo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Severance Cancer Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Gangnam Severance Hospital Yonsei University 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