{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:16:13Z","timestamp":1785770173780,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sleeve lobectomy represents a safe and effective treatment for central NSCLC to avoid the risks of pneumonectomy. Induction therapy (IT) may be indicated in advanced stages; however, the effect of IT on bronchial anastomoses remains uncertain. The purpose of the study was to evaluate the impact of IT on the complications of the anastomoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2000 and 2012, 159 consecutive patients were submitted to sleeve lobectomy for NSCLC at our Institution. We retrospectively compared the results of patients who underwent IT before operation with those who received upfront surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study period, 49 (30.8%) patients received IT (37 chemotherapy, 1\u00a0radiotherapy and 11 chemo\u2010radiotherapy) and 110 (69.2%) patients were directly submitted to surgery (S). The two groups were comparable for sex, age, comorbidities, ASA score, pulmonary function, side, type of procedure and histology. Pathological stage was statistically higher for IT group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). No differences between IT and S groups were observed in terms of post\u2010operative mortality (2% vs 0%, <jats:italic>p<\/jats:italic>\u2009=\u2009NS), morbidity (45% vs 38%, <jats:italic>p<\/jats:italic>\u2009=\u2009NS), including early (6% vs 9%, <jats:italic>p<\/jats:italic>\u2009=\u2009NS) and long\u2010term (16% vs 14%, <jats:italic>p<\/jats:italic>\u2009=\u2009NS) bronchial complication rates. Patients undergoing induction mediastinal radiotherapy, however, are at higher risk of bronchial complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our experience, the use of induction chemotherapy did not significantly increase mortality and morbidity rates, in particular, neither for early nor for late anastomotic complications. We, therefore, conclude that sleeve lobectomy after induction chemotherapy is safe and reliable procedure for the treatment of locally advanced NSCLC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-019-04908-0","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T16:49:31Z","timestamp":1547830171000},"page":"1385-1392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does Induction Therapy Increase Anastomotic Complications in Bronchial Sleeve Resections?"],"prefix":"10.1002","volume":"43","author":[{"given":"Giovanni M.","family":"Comacchio","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Schiavon","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Azzolina","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences University of Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mammana","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marulli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Emergency and Organ Transplantation University Hospital Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zuin","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Verderi","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Monaci","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Second Medical Oncology Unit Istituto Oncologico Veneto, IRCCS Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pasello","sequence":"additional","affiliation":[{"name":"Second Medical Oncology Unit Istituto Oncologico Veneto, IRCCS Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Rea","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardio\u2010Thoracic and Vascular Sciences University of Padova Via Giustiniani, 2 35128 Padua 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